ArticleFrontiers in cardiovascular medicine2022
Genetically Predicted Obesity Causally Increased the Risk of Hypertension Disorders in Pregnancy.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Glucose variability as a key mediator in the relationship between pre-pregnancy overweight/obesity and late-onset hypertensive disorders of pregnancy.Scientific reports · 2025Article
- Association between chronic obstructive pulmonary disease and osteoporosis: Mendelian randomization combined with bibliometric analysis.Hereditas · 2025Article
- Association between bone mineral density and scoliosis: a two-sample mendelian randomization study in european populations.Hereditas · 2024Article
- Inflammatory, metabolic, and endothelial biomarkers before and after pregnancy complications.American journal of epidemiology · 2024Article
- Article
- An inverse causal association between genetically predicted vitamin D and chronic obstructive pulmonary disease risk.Frontiers in nutrition · 2023Article
- Mendelian randomization to evaluate the causal relationship between liver enzymes and the risk of six specific bone and joint-related diseases.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: This study aimed to evaluate the causal association between obesity and hypertension disorders in pregnancy. Methods: Two-sample Mendelian randomization (MR) study was conducted based on the data obtained from the GIANT ( Results: All three MR methods showed that genetically predicted obesity causally increased the risk of hypertension disorders in pregnancy. IVW analysis provided obesity as a risk factor for hypertension disorders in pregnancy with an odds ratio (OR) of 1.39 [95% confidence interval (CI) 1.21-1.59; Conclusions: Our findings provided directed evidence that obesity was causally associated with a higher risk of hypertension disorders in pregnancy. Taking measures to reduce the proportion of obesity may help reduce the incidence of hypertension disorders in pregnancy.
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Registered trials
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