Evidence map›Paper›PMID 35694541›Full record

ArticleFrontiers in cellular and infection microbiology2022

Intestinal Alkaline Phosphatase Prevents Sulfate Reducing Bacteria-Induced Increased Tight Junction Permeability by Inhibiting Snail Pathway.

Sudha B Singh, Cristina N Coffman, Matthew G Varga, Amanda Carroll-Portillo, Cody A Braun, Henry C Lin

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. DietaryAnimals : an open access journal from MDPI · 2026
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  10. Protective Effects of Orally AdministeredInternational journal of nanomedicine · 2026
    Article
  11. Article
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  14. Review
  15. Review
  16. Article
  17. The Role of Bacteria-Derived Hydrogen Sulfide in Multiple Axes of Disease.International journal of molecular sciences · 2025
    Review
  18. Article
  19. Postbiotic Metabolite Derived fromAntibiotics (Basel, Switzerland) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sudha B SinghBiomedical Research Institute of New Mexico, New Mexico Veterans Affairs (VA) Health Care System, Albuquerque, NM, United States.
Cristina N CoffmanBiomedical Research Institute of New Mexico, New Mexico Veterans Affairs (VA) Health Care System, Albuquerque, NM, United States.
Matthew G VargaBiomedical Research Institute of New Mexico, New Mexico Veterans Affairs (VA) Health Care System, Albuquerque, NM, United States.
Amanda Carroll-PortilloDivision of Gastroenterology and Hepatology, Department of Medicine, University of New Mexico, Albuquerque, NM, United States.
Cody A BraunBiomedical Research Institute of New Mexico, New Mexico Veterans Affairs (VA) Health Care System, Albuquerque, NM, United States.
Henry C LinDivision of Gastroenterology and Hepatology, Department of Medicine, University of New Mexico, Albuquerque, NM, United States.
New Mexico VA Health Care System · USUniversity of New Mexico · USBiomedical Research Institute of New Mexico · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tight junctions (TJs) are essential components of intestinal barrier integrity and protect the epithelium against passive paracellular flux and microbial translocation. Dysfunctional TJ leads to leaky gut, a condition associated with diseases including inflammatory bowel disease (IBD). Sulfate-Reducing Bacteria (SRB) are minor residents of the gut. An increased number of

Indexed as

DesulfovibrioInflammatory Bowel DiseasesAlkaline PhosphataseBacteriaCaco-2 CellsFluorescein-5-isothiocyanateGPI-Linked ProteinsHumansIntestinal MucosaOccludinPermeabilitySulfatesTight JunctionsAlkaline PhosphataseALPI protein, humanFluorescein-5-isothiocyanateGPI-Linked ProteinsOccludinSulfatesDesulfovibrio vulgarisintestinal alkaline phosphatase (IAP)occludinsnailtransepithelial electrical resistance (TEER)

Identifiers

PMID35694541
PMCPMC9177943
OpenAlexW4281567197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.