Evidence map›Paper›PMID 35694449›Full record

ArticleLeukemia research reports2022

Daratumumab triplet therapies in patients with relapsed or refractory multiple myeloma: A "real world" experience.

Ludovica Fucci, Lorenzo Gensini, Ugo Coppetelli, Elettra Ortu La Barbera, Martina Gentile, Luciano Fiori, Salvatore Perrone, Giuseppe Cimino

Open access · goldAbstract readCase Reports
In one paragraph

Article in Leukemia research reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Experience of Daratumumab in Relapsed/Refractory Multiple Myeloma: A Multicenter Study from TürkiyeTurkish journal of haematology : official journal of Turkish Society of Haematology · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ludovica FucciDepartment of Translational and Precision Medicine, University of Rome "La Sapienza", Viale dell'Università, 37, Roma 00185, Italy.
Lorenzo GensiniDepartment of Translational and Precision Medicine, University of Rome "La Sapienza", Viale dell'Università, 37, Roma 00185, Italy.
Ugo CoppetelliHematology and Transplant Unit, Santa Maria Goretti Hospital, AUSL, Latina, Italy.
Elettra Ortu La BarberaHematology and Transplant Unit, Santa Maria Goretti Hospital, AUSL, Latina, Italy.
Martina GentileDepartment of Medical-Surgical Sciences and Biotechnologies, University of Rome "La Sapienza", Italy.
Luciano FioriHematology and Transplant Unit, Santa Maria Goretti Hospital, AUSL, Latina, Italy.
Salvatore PerroneHematology and Transplant Unit, Santa Maria Goretti Hospital, AUSL, Latina, Italy.
Giuseppe CiminoDepartment of Translational and Precision Medicine, University of Rome "La Sapienza", Viale dell'Università, 37, Roma 00185, Italy.
Ospedale Santa Maria Goretti · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report our retrospective analysis on 34 relapsed/refractory multiple myeloma (RRMM) patients treated with daratumumab based triplets. Twenty patients were females and 14 males. Median age was 73.2. Daratumumab was associated to lenalidomide in and dexamethasone (DRd) in 30 (88,3%) and to bortezomib and dexamethasone (DVd) in 4 cases (11,7%). The ORR was 88%. CR occurred in 12% of cases, VGPR in 44% and PR in 32%. The 12 months PFS and OS rates were 78% and 86,5%, respectively. Present data confirm those recently reported in the literature and further reinforce the early use of daratumumab-based triplets for RRMM patients.

Indexed as

DaratumumabMultiple myelomaReal-word experienceRelapsed refractory

Identifiers

PMID35694449
PMCPMC9184873
OpenAlexW4282040146

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.