Evidence map›Paper›PMID 35694353›Full record

ReviewChemical science2022

Oriented internal electrostatic fields: an emerging design element in coordination chemistry and catalysis.

Alexander B Weberg, Ryan P Murphy, Neil C Tomson

Abstract readReview
In one paragraph

Review in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Spatially Regulated Electrical Forces for Biological Catalysis.Reviews of physiology, biochemistry and pharmacology · 2025
    Review
  3. Electric fields imbue enzyme reactivity by aligning active site fragment orbitals.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Tuning Electrode Reactivity through Organometallic Complexes.ACS applied materials & interfaces · 2023
    Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexander B WebergR, oy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania 231 S. 34th Street Philadelphia Pennsylvania 19104 USA tomson@upenn.edu.ORCID https://orcid.org/0000-0001-8421-9760
Ryan P MurphyR, oy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania 231 S. 34th Street Philadelphia Pennsylvania 19104 USA tomson@upenn.edu.ORCID https://orcid.org/0000-0002-0700-2880
Neil C TomsonR, oy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania 231 S. 34th Street Philadelphia Pennsylvania 19104 USA tomson@upenn.edu.ORCID https://orcid.org/0000-0001-9131-1039

Funding

Modelling Enzymatic Electrostatic Field Effects with Coordination ChemistryR35GM128794 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Neil Carleton Tomson · 2018 to 2026
$3.4M
NIGMS NIH HHS R35 GM128794
6 · The paper itself

Abstract

The power of oriented electrostatic fields (ESFs) to influence chemical bonding and reactivity is a phenomenon of rapidly growing interest. The presence of strong ESFs has recently been implicated as one of the most significant contributors to the activity of select enzymes, wherein alignment of a substrate's changing dipole moment with a strong, local electrostatic field has been shown to be responsible for the majority of the enzymatic rate enhancement. Outside of enzymology, researchers have studied the impacts of "internal" electrostatic fields

Identifiers

PMID35694353
PMCPMC9116365

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.