ArticleChemical science2022
Angle-dependent strength of a single chemical bond by stereographic force spectroscopy.
Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Single-Chain Inherent Elasticity Reveals γ-Irradiation-Induced Backbone Reconstruction in Poly(Vinylidene Fluoride).Macromolecular rapid communications · 2026Article
- Single-Chain Studies Reveal that Neutral Poly(2-ethyl-2-oxazoline) Exhibits Polyelectrolyte-like Behavior in Aqueous Solutions.Polymer science & technology (Washington, D.C.) · 2026Article
- Highly Branched Sulfated Glycopolymers as Mucin Mimetics.Journal of the American Chemical Society · 2025Article
- Article
- Dynamics and Stability Mechanism of Lactoferrin-EPA During Emulsification Process: Insights from Macroscopic and Molecular Perspectives.Foods (Basel, Switzerland) · 2025Article
- Effect of Environmental pH on the Mechanics of Chitin and Chitosan: A Single-Molecule Study.Polymers · 2024Article
- Revealing the Control Mechanisms of pH on the Solution Properties of Chitin via Single-Molecule Studies.Molecules (Basel, Switzerland) · 2023Article
- Review
- Article
- Anisotropic Friction in a Ligand-Protein Complex.Nano letters · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A wealth of chemical bonds and polymers have been studied with single-molecule force spectroscopy, usually by applying a force perpendicular to the anchoring surface. However, the direction-dependence of the bond strength lacks fundamental understanding. Here we establish stereographic force spectroscopy to study the single-bond strength for various pulling angles. Surprisingly, we find that the apparent bond strength increases with increasing pulling angle relative to the anchoring surface normal, indicating a sturdy mechanical anisotropy of a chemical bond. This finding can be rationalized by a fixed pathway for the rupture of the bond, resulting in an effective projection of the applied pulling force onto a nearly fixed rupture direction. Our study is fundamental for the molecular understanding of the role of the direction of force application in molecular adhesion and friction. It is also a prerequisite for the nanoscale tailoring of the anisotropic strength of bottom-up designed materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.