ArticleJournal of pain research2022
Prevention and Treatment of Neuraxial Morphine-Induced Pruritus: A Scoping Review.
Article in Journal of pain research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Determination of the ED90 for Epidural Hydromorphone and Morphine for Postoperative Pain Using a Biased-Coin Up-and-Down Sequential Design After Elective Cesarean Delivery.Drug design, development and therapy · 2026Trial
- Induction of General Anesthesia with Fospropofol in Elderly Patients Undergoing Hip Surgery: An Efficacy and Safety Analysis.Drug design, development and therapy · 2026Trial
- Single epidural bolus hydromorphone for acute postpartum pain after vaginal delivery: a randomized clinical trial.Scientific reports · 2025Trial
- Comparison of the postoperative analgesic efficacy of the ultrasound-guided erector spinae plane block and intrathecal morphine in patients undergoing total abdominal hysterectomy under general anesthesia: a randomized controlled trial.Journal of anesthesia · 2025Trial
- Epidural injection of hydromorphone for postoperative pain after episiotomy: a randomized controlled trial.Scientific reports · 2024Trial
- Xiaofeng Granules alleviate intrathecal morphine-induced pruritus via inhibiting the NR2B/PKC/CAMK II signaling pathway.Journal of anesthesia · 2026Article
- Comparison of efficacy of quadratus lumborum block and intrathecal morphine in elective caesarean section for postoperative analgesia - A randomised controlled trial.Indian journal of anaesthesia · 2026Article
- Retrospective analysis of a failed introduction of intrathecal morphine in elective orthopaedic surgery.BMC musculoskeletal disorders · 2026Article
- Review
- Nalmefene effectively relieves thoracic epidural opioid-induced pruritus without affecting analgesia: a randomized controlled clinical trial.Journal of thoracic disease · 2025Article
- Review
- Effect of a lower dose of intrathecal morphine on postoperative opioid consumption following cesarean delivery at a Texas level IV maternal care center.Proceedings (Baylor University. Medical Center) · 2025Article
- Anesthesia effects of different doses of fospropofol disodium for painless colonoscopy diagnosis and treatment.Frontiers in medicine · 2025Article
- Postoperative Multimodal Analgesia Strategy for Enhanced Recovery After Surgery in Elderly Colorectal Cancer Patients.Pain and therapy · 2024Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The addition of morphine to neuraxial anaesthesia leads to improved postoperative analgesia and lower opioid consumption, but is often accompanied by pruritus. Studies on preventing or treating pruritus show contradictory results. Our objective was to identify effective drugs for the prevention or treatment of pruritus by a scoping review of clinical trials. A systematic literature search was conducted in PubMed, Embase and Web of Science. We identified clinical trials investigating the prevention or treatment of neuraxial morphine-induced pruritus in adults. Systematic reviews and meta-analyses were screened for eligible studies. One-hundred-and-four articles were included covering 13 pharmacological groups. We conclude that dopamine antagonists, µ-opioid agonist/antagonists and neuraxial or orally administered µ-opioid antagonists prevent pruritus caused by neuraxial morphine regardless of the timing of administration. In the reviewed literature, 5HT3-antagonists prevent neuraxial morphine-induced pruritus when administered before morphine administration. For the treatment of neuraxial morphine-induced pruritus, only nalbuphine appears to be consistently effective. More research is needed to find the most effective doses and the optimal timing of the effective medication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.