Evidence map›Paper›PMID 35693931›Full record

ArticleFrontiers in cell and developmental biology2022

Investigation of the Potential Mechanisms Underlying Nuclear F-Actin Organization in Ovarian Cancer Cells by High-Throughput Screening in Combination With Deep Learning.

Wei Wu, Xiaoxia Xing, Mingyang Wang, Yinzhou Feng, Nina Wietek, Kay Chong, Salma El-Sahhar, Ahmed Ashour Ahmed, Rongyu Zang, Yiyan Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Recent advances in nuclear actin research.Nucleus (Austin, Tex.) · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Wei WuDepartment of Gynecologic Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xiaoxia XingDepartment of Gynecologic Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
Mingyang WangSchool of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yinzhou FengDepartment of Gynecologic Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
Nina WietekOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Kay ChongOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Salma El-SahharOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Ahmed Ashour AhmedOvarian Cancer Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
Rongyu ZangDepartment of Gynecologic Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
Yiyan ZhengDepartment of Gynecologic Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
University of Oxford · GBZhongshan Hospital · CNFudan University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence supports the notion that filamentous actin (F-actin) and globular actin exist in the nuclei of somatic cells, and are involved in chromatin remodeling, gene transcription regulation and DNA damage repair. However, the underlying mechanisms of how nuclear F-actin are polymerized in cells remain incompletely understood. Here, we identify potential kinase targets that participate in nuclear F-actin polymerization in ovarian cancer cells using small-molecule inhibitor library screening in combination with a deep learning approach. The analysis of the targets of the inhibitors used in this study suggest that the PI3K-AKT pathway are involved in regulating nuclear F-actin organization in ovarian cancer cells. Our work lays the foundation for uncovering the important roles of nuclear F-actin in the context of ovarian cancer, and for understanding how nuclear F-actin structures are organized.

Indexed as

deep learninghigh-throughput screeningkinasenuclear F-actinovarian cancer

Identifiers

PMID35693931
PMCPMC9178185
OpenAlexW4281571037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.