Evidence map›Paper›PMID 35693872›Full record

ArticleDose-response : a publication of International Hormesis Society

The Protective Effects and Mechanism of Doxepin on Radiation-Induced Lung Injury in Rats.

Xinlong Wan, Xuan Shi, Mengke Li, Qing Chen, Chang Xue, Guanghui Li, Yeke Huang, Jingwen Yang, Chan Chen, Zhiyi Wang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Xinlong WanSouth ZheJiang Institute of Radiation Medicine and Nuclear Technology, Wenzhou Medical University, China.
Xuan ShiDepartment of Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, China.ORCID https://orcid.org/0000-0001-5991-7719
Mengke LiSouth ZheJiang Institute of Radiation Medicine and Nuclear Technology, Wenzhou Medical University, China.
Qing ChenSouth ZheJiang Institute of Radiation Medicine and Nuclear Technology, Wenzhou Medical University, China.
Chang XueSouth ZheJiang Institute of Radiation Medicine and Nuclear Technology, Wenzhou Medical University, China.
Guanghui LiSouth ZheJiang Institute of Radiation Medicine and Nuclear Technology, Wenzhou Medical University, China.
Yeke HuangThe Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, China.ORCID https://orcid.org/0000-0002-4573-7642
Jingwen YangDepartment of Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, China.
Chan ChenDepartment of Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical University, China.
Zhiyi WangDepartment of General Practice, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, China.
Shumei MaSouth ZheJiang Institute of Radiation Medicine and Nuclear Technology, Wenzhou Medical University, China.
Xiaodong LiuSouth ZheJiang Institute of Radiation Medicine and Nuclear Technology, Wenzhou Medical University, China.ORCID https://orcid.org/0000-0002-6879-990X
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation-induced lung injuries (RILI) is one of the serious complications of radiotherapy posed by the damage of alveolar cells and inflammation over-reaction. We aimed to investigate the potential protective effects of doxepin on RILI (20 Gy total dose at 3 Gy/min of X-ray irradiation), as well as its underlying mechanism. For animal experiments, such parameters as Immunohistochemistry and hematoxylin and eosin (H&E) staining, WBC (white blood cell), CRP (C-reactive protein), Western blot, and q-PCR were detected. The results indicated that both survival status and weight increase of irradiated rats treated by doxepin (3 mg/kg/day, rat) were higher than those of treated with irradiation alone (Dosing started the day before irradiation). Further, histological examinations showed doxepin could tenuate the radiation injury, as indicated as alveolar inflammatory exudation and there was only mild interstitial inflammation infiltration. Western blotting and q-PCR showed that expression of NF-κβ in X group were higher than that in XMD group. For the first time, we reported doxepin functioned as a radioprotectant candidate, which provide a promising application of doxepin for protecting radiotherapy injuries.

Indexed as

doxepinJNKNF-κβradiation-induced lung injuries

Identifiers

PMID35693872
PMCPMC9178985
OpenAlexW4281760956

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.