Evidence map›Paper›PMID 35693823›Full record

ArticleFrontiers in immunology2022

Differential Effects of Alarmins on Human and Mouse Basophils.

Adriana R Gambardella, Remo Poto, Valentina Tirelli, John T Schroeder, Gianni Marone, Fabrizio Mattei, Gilda Varricchi, Giovanna Schiavoni

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. TSLP: contrasting roles in cancer.Frontiers in immunology · 2025
    Review
  6. Innate Immune Cells in Melanoma: Implications for Immunotherapy.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Human Lung Mast Cells: Therapeutic Implications in Asthma.International journal of molecular sciences · 2022
    Review
  17. Article
  18. Basophils from allergy to cancer.Frontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Adriana R GambardellaDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità (ISS), Rome, Italy.
Remo PotoDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità (ISS), Rome, Italy.
Valentina TirelliCore Facilities, Istituto Superiore di Sanità (ISS), Rome, Italy.
John T SchroederDivision of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Gianni MaroneDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Fabrizio MatteiDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità (ISS), Rome, Italy.
Gilda VarricchiDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Giovanna SchiavoniDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità (ISS), Rome, Italy.
Istituto Superiore di Sanità · ITUniversity of Naples Federico II · ITInstitute for Experimental Endocrinology and Oncology · ITJohns Hopkins Medicine · US

Funding

Galectins in Modulating Immune Responsiveness of IgE-bearing CellsR01AI141486 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SCHROEDER, JOHN T. · 2019 to 2024
$2.6M
NIAID NIH HHS R01 AI141486
6 · The paper itself

Abstract

Epithelial-derived alarmins (IL-33, TSLP, and IL-25) play an upstream role in the pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic inflammation. We evaluated the

Indexed as

BasophilsInterleukin-33AlarminsAnimalsCytokinesHumansInterleukin-13Interleukin-3Interleukin-4MiceRNA, MessengerAlarminsCytokinesInterleukin-13Interleukin-3Interleukin-33Interleukin-4RNA, MessengerallergyasthmabasophilsIL-13IL-25IL-33IL-4TSLP

Identifiers

PMID35693823
PMCPMC9177950
OpenAlexW4281572391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.