Evidence map›Paper›PMID 35693759›Full record

ArticleAddiction neuroscience2022

Challenges and new opportunities for detecting endogenous opioid peptides in reward.

Sineadh M Conway, Marwa O Mikati, Ream Al-Hasani

Open access · goldAbstract read
In one paragraph

Article in Addiction neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Endogenous opioids and the development of the mammalian respiratory control network.American journal of physiology. Lung cellular and molecular physiology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sineadh M ConwayDepartment of Anesthesiology, Washington University, St Louis, MO, USA.
Marwa O MikatiDepartment of Anesthesiology, Washington University, St Louis, MO, USA.
Ream Al-HasaniDepartment of Anesthesiology, Washington University, St Louis, MO, USA.
University of Health Sciences and Pharmacy · US

Funding

DEFINING DYNORPHIN-CRF CIRCUITS IN STRESS AND NICOTINE BEHAVIORSR00DA038725 · NIDA · ST. LOUIS COLLEGE OF PHARMACY · PI AL-HASANI, REAM · 2017 to 2019
$747k
Rapid and sensitive in vivo detection of opioid peptidesR21DA048650 · NIDA · ST. LOUIS COLLEGE OF PHARMACY · PI AL-HASANI, REAM · 2019 to 2020
$441k
Understanding dynorphin and dopamine dynamics during fentanyl exposureF32DA053093 · NIDA · WASHINGTON UNIVERSITY · PI CONWAY, SINEADH MARGARET · 2021 to 2022
$136k
NIDA NIH HHS F32 DA053093NIDA NIH HHS R00 DA038725NIDA NIH HHS R21 DA048650
6 · The paper itself

Abstract

The endogenous opioid peptide system, comprised of enkephalins, endorphins, dynorphins, and nociceptin, is a highly complex neurobiological system. Opioid peptides are derived from four precursor molecules and undergo several processing events yielding over 20 unique opioid peptides. This diversity together with low

Indexed as

Drug rewardDynorphinEnkephalinFood rewardOpioid peptidesβ-endorphin

Identifiers

PMID35693759
PMCPMC9187278
OpenAlexW4224047104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.