ArticleTranslational andrology and urology2022
Mechanism of ferroptosis in hypertensive nephropathy.
Article in Translational andrology and urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Ferroptosis as a target mechanism in heart and kidney disease.The Journal of clinical investigation · 2026Review
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- Current perspectives and trends of the research on hypertensive nephropathy: a bibliometric analysis from 2000 to 2023.Renal failure · 2024Review
- Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulations Reveal the Mechanisms ofCurrent issues in molecular biology · 2024Article
- Network pharmacology and experimental verification study on the mechanism of Hedyotis diffusa Willd in treating colorectal cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Ferroptosis and secondary nephrosis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- Ferroptosis in organ fibrosis: From mechanisms to therapeutic medicines.Journal of translational internal medicine · 2024Article
- Non-coding RNAs are involved in tumor cell death and affect tumorigenesis, progression, and treatment: a systematic review.Frontiers in cell and developmental biology · 2024Review
- A ferroptosis-related LncRNAs signature for predicting prognoses and screening potential therapeutic drugs in patients with lung adenocarcinoma: A retrospective study.Cancer reports (Hoboken, N.J.) · 2024Article
- Diagnostic and therapeutic role of non-coding RNAs regulating programmed cell death in melanoma.Frontiers in oncology · 2024Review
- Multi-target mechanism ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Matrine Alleviates Sepsis-Induced Myocardial Injury by Inhibiting Ferroptosis and Apoptosis.Inflammation · 2023Article
- Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases.Cell death & disease · 2023Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In recent years, it has been demonstrated that ferroptosis can be involved in a variety of kidney injury processes, but the role played by ferroptosis in hypertensive kidney injury is still unclear. The aim was to explore the mechanism of ferroptosis playing a role in hypertensive kidney disease and related signalling pathways. Methods: GSE37455 microarray data was downloaded from the Gene Expression Omnibus (GEO) database and preprocessed. Batch correction and differential analysis were performed on the normal population and the hypertensive nephropathy samples using the "sva" and "limma" packages in R software. Ferroptosis-related genes were obtained from the FerrDb database and normalized and processed using UniProt. Ferroptosis-related differentially expressed genes were obtained using Venny 2.1. and imported into the Search Tool for the Retrieval of Interacting Genes (STRING) to obtain protein-protein interactions (PPIs). The data were imported into Cytoscape 3.7.2 for processing to identify the core differential genes of ferroptosis based on nodes. Gene set enrichment analysis (GSEA) was performed on the core differential genes of ferroptosis to infer the pathway of ferroptosis action in hypertensive nephropathy. Results: The R software processing yielded 37 differential genes, including 13 upregulated genes and 24 downregulated genes. 202 ferroptosis-related genes were obtained by screening, and 3 ferroptosis-related differentially expressed genes were obtained after taking the intersection. The ferroptosis-related core differentially expressed gene albumin ( Conclusions: Ferroptosis may act in the development of hypertensive nephropathy through pathways such as BCAA metabolism and retinol metabolism and BPs such as organic and amino acid metabolism and humoral immunity.
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