Evidence map›Paper›PMID 35693705›Full record

ArticleOxidative medicine and cellular longevity2022

Activated Stellate Cell Paracrine HGF Exacerbated Pancreatic Cancer Cell Ferroptosis Resistance.

Qiwei Wu, Lian Song, Yaxin Guo, Sai Liu, Wenyao Wang, Huli Liu, Aihua Gong, Xiang Liao, Haitao Zhu, Dongqing Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Qiwei WuDepartment of Medical Imaging, The Affiliated Hospital of Jiangsu University, Zhenjiang, China 212001.ORCID https://orcid.org/0000-0003-4531-5682
Lian SongDepartment of Medical Imaging, The Affiliated Hospital of Jiangsu University, Zhenjiang, China 212001.
Yaxin GuoDepartment of Medical Imaging, The Affiliated Hospital of Jiangsu University, Zhenjiang, China 212001.
Sai LiuDepartment of Medical Imaging, The Affiliated Hospital of Jiangsu University, Zhenjiang, China 212001.
Wenyao WangDepartment of Medical Imaging, The Affiliated Hospital of Jiangsu University, Zhenjiang, China 212001.
Huli LiuDepartment of Medical Imaging, The Affiliated Hospital of Jiangsu University, Zhenjiang, China 212001.
Aihua GongSchool of Medicine, Jiangsu University, Zhenjiang, China 212013.
Xiang LiaoDepartment of Medical Laboratory, The Affiliated Hospital of Jiangsu University, Zhenjiang, China 212001.ORCID https://orcid.org/0000-0002-0669-6366
Haitao ZhuDepartment of Medical Imaging, The Affiliated Hospital of Jiangsu University, Zhenjiang, China 212001.ORCID https://orcid.org/0000-0002-4168-4053
Dongqing WangDepartment of Medical Imaging, The Affiliated Hospital of Jiangsu University, Zhenjiang, China 212001.ORCID https://orcid.org/0000-0002-4314-9687
Jiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a refractory tumor, pancreatic carcinoma is more vulnerable to ferroptosis, a novel regulated cell death mode. However, the exact role of pancreatic stellate cells (PSCs) in pancreatic cancer ferroptosis is still unclear. Using the coculture system, we revealed that activated PSCs promote pancreatic cancer cell ferroptosis resistance. Mechanistically, activated PSCs secreted HGF, which further activated the HGF receptor, c-MET, in pancreatic cancer cells, prevented lipid peroxidation, and ultimately triggered pancreatic cancer cell ferroptosis resistance

Indexed as

FerroptosisPancreatic NeoplasmsCell Line, TumorHepatocyte Growth FactorHumansPancreatic Stellate CellsHepatocyte Growth FactorHGF protein, human

Identifiers

PMID35693705
PMCPMC9177329
OpenAlexW4281700739

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.