ArticleEuropean journal of pediatrics1987
Amplification and expression of the N-myc gene in neuroblastoma.
Article in European journal of pediatrics, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 58 citations in OpenAlex.
- Calreticulin Expression Controls Cellular Redox, Stemness, and Radiosensitivity to Function as a Novel Adjuvant for Radiotherapy in Neuroblastoma.Oxidative medicine and cellular longevity · 2023Article
- MYCN is amplified during S phase, and c‑myb is involved in controlling MYCN expression and amplification in MYCN‑amplified neuroblastoma cell lines.Molecular medicine reports · 2019Article
- Article
- A novel intron element operates posttranscriptionally To regulate human N-myc expression.Molecular and cellular biology · 1999Article
- Dup 3(q) syndrome and neuroblastoma.European journal of pediatrics · 1992Article
- Overexpression of multiple oncogenes related to histological grade of astrocytic glioma.British journal of cancer · 1992Article
- Cloning and physical mapping of DNA sequences encompassing a region in N-myc amplicons of a human neuroblastoma cell line.Nucleic acids research · 1991Article
- Biology of tumors of the peripheral nervous system.Cancer metastasis reviews · 1991Review
- Analysis of DNA ploidy and proliferative activity in relation to histology and N-myc amplification in neuroblastoma.The American journal of pathology · 1990Article
- Abdominal, retroperitoneal and sacrococcygeal tumours of the newborn and the very young infant. Report from the Kiel Paediatric Tumour Registry.European journal of pediatrics · 1989Article
- Incidence of ras gene mutations in neuroblastoma.European journal of pediatrics · 1988Article
- Genetics of congenital solid tumors.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic configuration and expression of the N-myc gene was investigated by Southern and Northern blot analyses in 18 neuroblastomas of different clinical stages. We observed a 4-100-fold amplification of this oncogene in one of six stage III, two of four stage IV as well as one of five stage IVS tumours. Remarkably, an 80-fold N-myc amplification was demonstrated in a patient with stage IV neuroblastoma being in remission for more than 2 years; moreover, a 100-fold amplification could be detected in a stage IVS tumour from a newborn. These data are discussed in view of the recently postulated close association of N-myc amplification with rapid progression of neuroblastomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.