Evidence map›Paper›PMID 35693217›Full record

ArticlePrecision clinical medicine2021

A case report of response to crizotinib in chemotherapy-refractory metastatic gallbladder cancer with met amplification and acquired resistance resulting from the loss of MET amplification.

Hongna Sun, Xiaofen Li, Shuang Dai, Xudong Shen, Meng Qiu

Open access · diamondAbstract read
In one paragraph

Article in Precision clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hongna SunDepartment of Abdominal Cancer, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Xiaofen LiDepartment of Abdominal Cancer, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Shuang DaiDepartment of Medical Oncology, Lung cancer center, West China Hospital, Sichuan University, Chengdu 611135, China.
Xudong ShenThe Medical Department, 3D Medicines Inc., Shanghai 201202, China.
Meng QiuDepartment of Abdominal Cancer, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gallbladder cancer (GBC) is a highly invasive disease and the most prevalent malignancy of the biliary system. Patients with GBC are commonly diagnosed at a late stage and have an unfavorable prognosis. Palliative chemotherapy has been the standard care for recurrent or metastatic disease in the past decades. Recently, several targeted therapies have been investigated in advanced biliary tract cancer (BTC) including inhibitors of genes or pathways such as

Indexed as

acquired resistance; case reportctDNAMET amplificationmetastatic gallbladder cancertargeted therapy

Identifiers

PMID35693217
PMCPMC8982584
OpenAlexW3189751776

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.