Evidence map›Paper›PMID 35693070›Full record

ArticleAmerican journal of cancer research2022

Decoding the multidimensional signatures of resident and expanded natural killer cells generated from perinatal blood.

Leisheng Zhang, Min Liu, Baoquan Song, Wenjing Miao, Rucai Zhan, Sijun Yang, Zhihai Han, Hui Cai, Xianghong Xu, Yixiao Zhao and 4 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Leisheng ZhangKey Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province & NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital Lanzhou 730000, Gansu, China.
Min LiuVeterinary Bureau, Department agriculture and Animal Husbandry of Inner Mongolia Autonomous Region Hohhot 010011, China.
Baoquan SongNational Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, China.
Wenjing MiaoNational Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, China.
Rucai ZhanCenter for Cellular Therapies, The First Affiliated Hospital of Shandong First Medical University Jinan 250014, Shandong, China.
Sijun YangJiangxi Research Center of Stem Cell Engineering, Jiangxi Health-Biotech Stem Cell Technology Co., Ltd. Shangrao 334000, Jiangxi, China.
Zhihai HanJiangxi Research Center of Stem Cell Engineering, Jiangxi Health-Biotech Stem Cell Technology Co., Ltd. Shangrao 334000, Jiangxi, China.
Hui CaiKey Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province & NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital Lanzhou 730000, Gansu, China.
Xianghong XuDepartment of Biotherapy Center, Gansu Provincial Hospital Lanzhou 730000, Gansu, China.
Yixiao ZhaoCollege of Food Science and Engineering, Northwest Agriculture & Forestry University Yangling 712100, Shaanxi, China.
Zhongchao HanInstitute of Health-Biotech, Health-Biotech (Tianjin) Stem Cell Research Institute Co., Ltd. Tianjin 301701, China.
Tiankang GuoKey Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province & NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital Lanzhou 730000, Gansu, China.
Jun YaoSchool and Hospital of Stomatology, Fujian Medical University Fuzhou 350002, Fujian, China.
Qing HuangKey Laboratory of Radiation Technology and Biophysics, Hefei Institute of Physical Science, Chinese Academy of Sciences Hefei 230031, Anhui, China.
Gansu Provincial Hospital · CNCell Technology (China) · CNSoochow University · CNFujian Medical University · CNGuizhou University · CNHefei Institutes of Physical Science · CNInner Mongolia Academy of Agricultural & Animal Husbandry Sciences · CNNorth West Agriculture and Forestry University · CNShandong First Medical University · CNSinovac Biotech · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer (NK) cells are lymphocytes and play a pivotal role in innate and adaptive immune responses against infections and malignancies. Longitudinal studies have indicated the feasibility of perinatal blood for large-scale NK cell generation, yet the systematic and detailed comparations of the signatures of resident and expanded NK cells (rNKs, eNKs) are largely obscure. Herein, we harvested rNKs from umbilical cord blood (rUC-NKs) and placental blood (rP-NKs) as well as the corresponding eNKs (eUC-NKs, eP-NKs). Furthermore, the biological properties and transcriptomic signatures including cellular subpopulations, cytotoxicity, gene expression profiling, genetic characteristics, signaling pathways and gene set-related biological process were investigated. The enriched rNKs and eNKs exhibited diversity in biomarker expression pattern, and eNKs with higher percentages of NKG2D

Indexed as

biological phenotypeexpanded NK cells (eNKs)Perinatal bloodresident NK cells (rNKs)transcriptomic signatures

Identifiers

PMID35693070
PMCPMC9185604
OpenAlexW4285741519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.