Evidence map›Paper›PMID 35693026›Full record

ArticleFrontiers in neural circuits2022

Inhibitory NPY Neurons Provide a Large and Heterotopic Commissural Projection in the Inferior Colliculus.

Justin D Anair, Marina A Silveira, Pooyan Mirjalili, Nichole L Beebe, Brett R Schofield, Michael T Roberts

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neural circuits, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. bioRxiv : the preprint server for biology · 2026
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  14. Neuropeptide Y Signaling Regulates Recurrent Excitation in the Auditory Midbrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Justin D AnairKresge Hearing Research Institute, Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, United States.
Marina A SilveiraKresge Hearing Research Institute, Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, United States.
Pooyan MirjaliliDepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH, United States.
Nichole L BeebeDepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH, United States.
Brett R SchofieldDepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH, United States.
Michael T RobertsKresge Hearing Research Institute, Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, United States.
Northeast Ohio Medical University · USUniversity of Michigan–Ann Arbor · US

Funding

Modulatory Circuits in the Auditory SystemR01DC004391 · NIDCD · UNIVERSITY OF LOUISVILLE · PI SCHOFIELD, BRETT R · 1999 to 2025
$9.9M
Circuit Mechanisms for Auditory Processing in the Inferior ColliculusR01DC018284 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROBERTS, MICHAEL THOMAS · 2020 to 2024
$2.3M
GABA and NPY Signaling Interact to Shape Inhibition in the Auditory Tectothalamic PathwayK99DC019415 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SILVEIRA, MARINA AUGUSTO · 2022 to 2023
$278k
NIDCD NIH HHS K99 DC019415NIDCD NIH HHS R01 DC004391NIDCD NIH HHS R01 DC018284
6 · The paper itself

Abstract

Located in the midbrain, the inferior colliculus (IC) plays an essential role in many auditory computations, including speech processing and sound localization. The right and left sides of the IC are interconnected by a dense fiber tract, the commissure of the IC (CoIC), that provides each IC with one of its largest sources of input (i.e., the contralateral IC). Despite its prominence, the CoIC remains poorly understood. Previous studies using anterograde and retrograde tract-tracing showed that IC commissural projections are predominately homotopic and tonotopic, targeting mirror-image locations in the same frequency region in the contralateral IC. However, it is unknown whether specific classes of neurons, particularly inhibitory neurons which constitute ~10%-40% of the commissural projection, follow this pattern. We, therefore, examined the commissural projections of Neuropeptide Y (NPY) neurons, the first molecularly identifiable class of GABAergic neurons in the IC. Using retrograde tracing with Retrobeads (RB) in NPY-hrGFP mice of both sexes, we found that NPY neurons comprise ~11% of the commissural projection. Moreover, focal injections of Retrobeads showed that NPY neurons in the central nucleus of the IC exhibit a more divergent and heterotopic commissural projection pattern than non-NPY neurons. Thus, commissural NPY neurons are positioned to provide lateral inhibition to the contralateral IC. Through this circuit, sounds that drive activity in limited regions on one side of the IC likely suppress activity across a broader region in the contralateral IC.

Indexed as

Inferior ColliculiSound LocalizationAnimalsAuditory PathwaysFemaleGABAergic NeuronsMaleMesencephalonMiceNeuropeptide YNeuropeptide Yauditorybinauralcommissureinferior colliculusinhibitionneuropeptide Yretrograde tracing

Identifiers

PMID35693026
PMCPMC9178209
OpenAlexW4281560617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.