Evidence map›Paper›PMID 35692801›Full record

ArticleFrontiers in oncology2022

Peripheral Organ Equivalent Dose Estimation Procedure in Proton Therapy.

Carles Domingo, Juan Ignacio Lagares, Maite Romero-Expósito, Beatriz Sánchez-Nieto, Jaime J Nieto-Camero, Jose Antonio Terrón, Leticia Irazola, Alexandru Dasu, Francisco Sánchez-Doblado

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 4 countries.

Carles DomingoDepartament de Fisica, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Juan Ignacio LagaresUnidad de Aplicaciones Médicas, Departamento de Tecnología, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain.
Maite Romero-ExpósitoThe Skandion Clinic, Uppsala, Sweden.
Beatriz Sánchez-NietoInstituto de Física, Pontificia Universidad Católica de Chile, Santiago, Chile.
Jaime J Nieto-CameroMedical Radiation Group, iThemba Labs, Faure, South Africa.
Jose Antonio TerrónServicio de Radiofísica, Hospital Universitario Virgen Macarena, Sevilla, Spain.
Leticia IrazolaServicio de Radiofísica y Protección Radiológica, Clínica Universidad de Navarra, Pamplona, Spain.
Alexandru DasuThe Skandion Clinic, Uppsala, Sweden.
Francisco Sánchez-DobladoDpto Fisiología Médica y Biofísica, Universidad de Sevilla, Sevilla, Spain.
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas · ESClinica Universidad de Navarra · ESHospital Universitario Virgen Macarena · ESiThemba Laboratory · ZAPontificia Universidad Católica de Chile · CLUniversidad de Sevilla · ESUniversitat Autònoma de Barcelona · ESUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this work is to present a reproducible methodology for the evaluation of total equivalent doses in organs during proton therapy facilities. The methodology is based on measuring the dose equivalent in representative locations inside an anthropomorphic phantom where photon and neutron dosimeters were inserted. The Monte Carlo simulation was needed for obtaining neutron energy distribution inside the phantom. The methodology was implemented for a head irradiation case in the passive proton beam of iThemba Labs (South Africa). Thermoluminescent dosimeter (TLD)-600 and TLD-700 pairs were used as dosimeters inside the phantom and GEANT code for simulations. In addition, Bonner sphere spectrometry was performed inside the treatment room to obtain the neutron spectra, some relevant neutron dosimetric quantities per treatment Gy, and a percentual distribution of neutron fluence and ambient dose equivalent in four energy groups, at two locations. The neutron spectrum at one of those locations was also simulated so that a reasonable agreement between simulation and measurement allowed a validation of the simulation. Results showed that the total out-of-field dose equivalent inside the phantom ranged from 1.4 to 0.28 mSv/Gy, mainly due to the neutron contribution and with a small contribution from photons, 10% on average. The order of magnitude of the equivalent dose in organs was similar, displaying a slow reduction in values as the organ is farther from the target volume. These values were in agreement with those found by other authors in other passive beam facilities under similar irradiation and measurement conditions.

Indexed as

neutron and photon doseneutron spectrometryperipheral organ doseproton therapysecondary cancer risk

Identifiers

PMID35692801
PMCPMC9176390
OpenAlexW4281490279

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.