ArticleJournal of clinical biochemistry and nutrition2022
Changes in plasma-concentration ratios of branched-chain amino acids in acute and convalescent phases of bacterial pneumonia.
Article in Journal of clinical biochemistry and nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Polyacrylic acid, but not polyethylene glycol, induces metabolic reprogramming linked to pulmonary fibrosis in rats.Scientific reports · 2025Article
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Abstract
Branched-chain amino acids (BCAAs) have different immunity-related functions. Thus, BCAAs require evaluation in terms of their plasma concentration ratio. Eighty healthy participants and 57 patients with community-acquired pneumonia were enrolled. Samples from the healthy participants were collected after 12-h fasting; samples from the community-acquired pneumonia group were collected 2-3 h after lunch, during the acute (day 0) and convalescent (day 7) phases. The coefficient "a" of the regression line (Y = aX + b) of each BCAA plasma concentration was calculated from healthy participants and fixed, and each intercept "b" was calculated from the plasma concentration of each BCAA pair. Isoleucine levels increased; no significant changes in leucine concentrations were observed between healthy participants and pneumonia patients on days 0 and 7. In female participants in the pneumonia group, valine concentrations decreased on day 0. The isoleucine concentration was relatively higher than the leucine concentration on day 7 when evaluated with "b". Changes in "b" on days 0 and 7 differed between men and women. There were sex-related differences in the plasma concentration ratios of BCAAs evaluated by "b", which indicates a possible sex-related difference in the metabolic response to bacterial infection.
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