Evidence map›Paper›PMID 35692497›Full record

ReviewJournal of immunology research2022

Immunotherapy and Antivascular Targeted Therapy in Patients' Treatment with Concurrent Malignant Tumors after Organ Transplantation: Opportunity or Challenge.

Bairu Shen, Zi Guo, Peng Huang, Minghua Tan, Xiaoshen Zhang, Siyao Lin, Changshan Song, Jiaqing Wang, Minqian Huang

Open access · goldAbstract readReview
In one paragraph

Review in Journal of immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Bairu ShenThoracic Surgery, Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Guangdong Province, China.ORCID https://orcid.org/0000-0001-9236-8096
Zi GuoThoracic Surgery, Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Guangdong Province, China.ORCID https://orcid.org/0000-0001-8144-4698
Peng HuangThoracic Surgery, Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Guangdong Province, China.ORCID https://orcid.org/0000-0001-7163-9758
Minghua TanThoracic Surgery, Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Guangdong Province, China.
Xiaoshen ZhangCardiac Surgery, The First Affiliated Hospital of Jinan University, Guangdong Province, China.
Siyao LinThoracic Surgery, Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Guangdong Province, China.ORCID https://orcid.org/0000-0002-3857-6107
Changshan SongThoracic Surgery, Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Guangdong Province, China.ORCID https://orcid.org/0000-0003-3437-4943
Jiaqing WangThoracic Surgery, Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Guangdong Province, China.ORCID https://orcid.org/0000-0002-4477-1953
Minqian HuangThoracic Surgery, Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Guangdong Province, China.ORCID https://orcid.org/0000-0002-6178-254X
Guangzhou University of Chinese Medicine · CNFirst Affiliated Hospital of Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To analyze the therapeutic effects and organ rejection of anti-PD-1 immunotherapy or antivascular targeting therapy on patients with combined malignancies after organ transplantation. Methods: We collected retrospective studies on "post-transplantation, cancer, immunotherapy, and vascular targeting therapy" in Embase, Wanfang database, Cochrane Library, VIP databases, CNKI, and PubMed, and the case data were organized and analyzed. Results: Data from only 40 papers met our requirements, which included 2 literature reviews, 4 original researches, and 34 case reports from 2016 to 2020. A total of 40 studies involving 66 patients were included, who were divided into 3 groups (patients using CTLA-4 inhibitors, group 1; patients who received sequential or concurrent anti-PD-1 and anti-CTLA-4 therapy, group 2; and patients using PD-1/PD-L1 inhibitors, group 3). There was no statistical difference in patients' DCR between the three groups ( Conclusions: Immunotherapy should be carefully selected for patients with combined malignancies after organ transplantation. Antivascular targeted therapy is one of the options worth considering; the risk of side effects of drug therapy is something that needs to be closely monitored when combined with immunotherapy.

Indexed as

NeoplasmsOrgan TransplantationHumansImmune Checkpoint InhibitorsImmunologic FactorsImmunotherapyRetrospective StudiesImmune Checkpoint InhibitorsImmunologic Factors

Identifiers

PMID35692497
PMCPMC9184147
OpenAlexW4281683633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.