Evidence map›Paper›PMID 35692470›Full record

ArticleJournal of parasitic diseases : official organ of the Indian Society for Parasitology2022

Co-administration of chloroquine and coenzyme Q

David B Ouko, Peris W Amwayi, Lucy A Ochola, Peninah M Wairagu, Alfred Orina Isaac, James N Nyariki

Open access · greenAbstract read
In one paragraph

Article in Journal of parasitic diseases : official organ of the Indian Society for Parasitology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

David B OukoDepartment of Biochemistry and Biotechnology, The Technical of University of Kenya, P.O Box, Nairobi, 52428-00200 Kenya.
Peris W AmwayiDepartment of Biochemistry and Biotechnology, The Technical of University of Kenya, P.O Box, Nairobi, 52428-00200 Kenya.
Lucy A OcholaDepartment of Tropical and Infectious Diseases, Institute of Primate Research, P.O Box, Karen, 24481-00502 Kenya.
Peninah M WairaguDepartment of Biochemistry and Biotechnology, The Technical of University of Kenya, P.O Box, Nairobi, 52428-00200 Kenya.
Alfred Orina IsaacDepartment of Pharmaceutical Sciences and Technology - School Health Sciences and Biomedical Sciences, The Technical University of Kenya, P.O Box, Nairobi, 52428-00200 Kenya.
James N NyarikiDepartment of Biochemistry and Biotechnology, The Technical of University of Kenya, P.O Box, Nairobi, 52428-00200 Kenya.ORCID 0000-0002-3213-7824
Technical University of Kenya · KEInstitute of Primate Research · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Development of cerebral malaria (CM) is driven by parasitemia levels, harmful inflammatory response, oxidative stress and consequent breach of the blood brain barrier. Use of adjunct therapy that utilizes an antioxidant and anti-inflammatory agent alongside chloroquine (CQ), may improve treatment outcome and shorten recovery from post-infection sequelae. Though withdrawn in some countries, CQ is still in use for prophylaxis and treatment of malaria in many countries. Current study investigated whether oral co-administration of 50 mg/kg CQ and 200 mg/kg of coenzyme Q

Indexed as

ChloroquineCoenzyme Q10Experimental cerebral malariaInflammationOxidative stress

Identifiers

PMID35692470
PMCPMC9177935
OpenAlexW4210671665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.