Evidence map›Paper›PMID 35692441›Full record

ArticleNano research2022

Emerging prospects of protein/peptide-based nanoassemblies for drug delivery and vaccine development.

Taiyu Liu, Lu Li, Cheng Cheng, Bingfang He, Tianyue Jiang

Abstract read
In one paragraph

Article in Nano research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Taiyu LiuSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816 China.
Lu LiSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816 China.
Cheng ChengSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816 China.
Bingfang HeSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816 China.
Tianyue JiangSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteins have been widely used in the biomedical field because of their well-defined architecture, accurate molecular weight, excellent biocompatibility and biodegradability, and easy-to-functionalization. Inspired by the wisdom of nature, increasing proteins/peptides that possess self-assembling capabilities have been explored and designed to generate nanoassemblies with unique structure and function, including spatially organized conformation, passive and active targeting, stimuli-responsiveness, and high stability. These characteristics make protein/peptide-based nanoassembly an ideal platform for drug delivery and vaccine development. In this review, we focus on recent advances in subsistent protein/peptide-based nanoassemblies, including protein nanocages, virus-like particles, self-assemblable natural proteins, and self-assemblable artificial peptides. The origin and characteristics of various protein/peptide-based assemblies and their applications in drug delivery and vaccine development are summarized. In the end, the prospects and challenges are discussed for the further development of protein/peptide-based nanoassemblies.

Indexed as

controlled releasedrug deliveryprotein/peptideself-assemblytargetingvaccine

Identifiers

PMID35692441
PMCPMC9166156

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.