Evidence map›Paper›PMID 35692424›Full record

ArticleFrontiers in neuroscience2022

Three-Photon Adaptive Optics for Mouse Brain Imaging.

David Sinefeld, Fei Xia, Mengran Wang, Tianyu Wang, Chunyan Wu, Xusan Yang, Hari P Paudel, Dimitre G Ouzounov, Thomas G Bifano, Chris Xu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
10.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

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  9. Visualizing Epigenetics: A Review of Microscopy Techniques for Investigating DNA Methylation Patterns, Chromatin Structure, and Gene Expression.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2025
    Review
  10. Article
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  14. Article
  15. Article
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  17. Article
  18. Long-termbioRxiv : the preprint server for biology · 2023
    Article
  19. Article
  20. Adaptive optics for optical microscopy [Invited].Biomedical optics express · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

David SinefeldSchool of Applied and Engineering Physics, Cornell University, Ithaca, NY, United States.
Fei XiaSchool of Applied and Engineering Physics, Cornell University, Ithaca, NY, United States.
Mengran WangSchool of Applied and Engineering Physics, Cornell University, Ithaca, NY, United States.
Tianyu WangSchool of Applied and Engineering Physics, Cornell University, Ithaca, NY, United States.
Chunyan WuSchool of Applied and Engineering Physics, Cornell University, Ithaca, NY, United States.
Xusan YangSchool of Applied and Engineering Physics, Cornell University, Ithaca, NY, United States.
Hari P PaudelPhotonics Center, Boston University, Boston, MA, United States.
Dimitre G OuzounovSchool of Applied and Engineering Physics, Cornell University, Ithaca, NY, United States.
Thomas G BifanoPhotonics Center, Boston University, Boston, MA, United States.
Chris XuSchool of Applied and Engineering Physics, Cornell University, Ithaca, NY, United States.
Cornell University · USBoston University · USJerusalem College of Technology · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three-photon microscopy (3PM) was shown to allow deeper imaging than two-photon microscopy (2PM) in scattering biological tissues, such as the mouse brain, since the longer excitation wavelength reduces tissue scattering and the higher-order non-linear excitation suppresses out-of-focus background fluorescence. Imaging depth and resolution can further be improved by aberration correction using adaptive optics (AO) techniques where a spatial light modulator (SLM) is used to correct wavefront aberrations. Here, we present and analyze a 3PM AO system for

Indexed as

adaptive opticsbrain imagingin vivo imagingmultiphoton microcopythree-photon microscopy

Identifiers

PMID35692424
PMCPMC9185169
OpenAlexW4281395148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.