ArticleFrontiers in endocrinology2022
The Relationship Between Obesity and Depression Is Partly Dependent on Metabolic Health Status: A Nationwide Inpatient Sample Database Study.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glucagon-like peptide-1 receptor agonists and risk of depression: a systematic review and meta-analysis.BMC psychiatry · 2026Pooled it
- The impact of 4-week high-intensity interval training on mental health and sleep quality in female college students with normal weight obesity: a randomized controlled trial.Journal of translational medicine · 2025Trial
- Article
- Beyond weight loss: Integrating GLP-1 RA therapies into psychological and behavioral care for obesity and binge eating disorder.Reviews in endocrine & metabolic disorders · 2026Review
- Association of Academic Level and Body Mass Index with Depressive Symptoms Among Undergraduate and Graduate Students in Bronx, NY: A Cross-Sectional Study.Behavioral sciences (Basel, Switzerland) · 2026Article
- Exploring the mediating roles of diet and physical activity in the association between different obesity phenotypes and risk of depression: A cox survival analysis approach.Comprehensive psychoneuroendocrinology · 2026Article
- Impact of Obesity, Menopause, and Depression in Women's Health: An Attempt to Decipher the Complex Relationship.Current medicinal chemistry · 2026Review
- Parallel Pathways, Divergent Outcomes: Adipose Tissue-Neural Crosstalk in Depression and Obesity.Journal of clinical medicine · 2025Review
- Associations between metabolic obesity phenotypes and prostate cancer in the U.S. population: a cross-sectional study.Translational andrology and urology · 2025Article
- Depression and its relationship to physical activity, sedentary behaviour, and body mass index (BMI) in Malaysian adolescents: a cross-sectional study.Archives of public health = Archives belges de sante publique · 2025Article
- Asthma risk: the inseparable synergy of obesity and metabolism.BMC pulmonary medicine · 2025Article
- The Role of Adipokines and Gene Polymorphisms in the Development of Obesity- Induced Depression.Current obesity reports · 2025Review
- Curvilinear association between cardiometabolic index and depressive symptoms in individuals aged 45 and older: a cross-sectional study of CHARLS.Frontiers in public health · 2025Article
- Nonlinear Association Between BMI and Depression Among Nonalcoholic Fatty Liver Disease: NHANES (2017-2018).Behavioural neurology · 2025Article
- The evaluation of depression prevalence and its association with obesity phenotypes in a community-dwelling aged population.Aging clinical and experimental research · 2024Article
- Early versus late-onset of weight struggles among patients with obesity: Data from the ACTION-IO study.Journal of family medicine and primary care · 2024Article
- Factors Associated with the Development of Depression and the Influence of Obesity on Depressive Disorders: A Narrative Review.Biomedicines · 2024Review
- Metabolic Health, Overweight or Obesity, and Depressive Symptoms among Older Australian Adults.Nutrients · 2024Article
- Transition in metabolic health phenotypes across general adiposity categories and association with the risk of depression: a prospective analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Depression in Women: Potential Biological and Sociocultural Factors Driving the Sex Effect.Neuropsychobiology · 2024Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Some studies have demonstrated a bidirectional association between obesity and depression, whereas others have not. This discordance might be due to the metabolic health status. We aimed to determine whether the relationship between obesity and depression is dependent on metabolic health status. Methods: In total, 9,022,089 participants were enrolled and classified as one of four obesity phenotypes: metabolically healthy nonobesity (MHNO), metabolically unhealthy nonobesity (MUNO), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUO). We then divided the population into eight phenotypes based on obesity and the number of metabolic risk factors. Furthermore, the associations of eight phenotypes, based on obesity and specific metabolic risk factors, with depression were assessed. Result: Among all participants, a higher risk of depression was observed for MUNO, MHO and MUO than for MHNO. The risk was highest for MUO (OR = 1.442; 95% CI = 1.432, 1.451). However, the association between MHO and depression was different for men and women (OR = 0.941, men; OR = 1.132, women). The risk of depression increased as the number of metabolic risk factors increased. Dyslipidemia was the strongest metabolic risk factor. These relationships were consistent among patients ≥ 45 years of age. Conclusions: The increased risk of obesity-related depression appears to partly depend on metabolic health status. The results highlight the importance of a favorable metabolic status, and even nonobese populations should be screened for metabolic disorders.
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