ArticleClinical and translational medicine2022
DNA methylation patterns reflect individual's lifestyle independent of obesity.
Article in Clinical and translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Molecular Effects of Physical Activity and Body Composition: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2025Pooled it
- Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study.Clinical epigenetics · 2026Article
- DNA methylation signature of cognitive reserve moderates CSF tau pathology in prodromal Alzheimer's disease.Research square · 2026Article
- Investigation of psychosocial stress and DNA methylation in genes related to immune response, metabolism, and calcium signaling among African American and White middle-aged adults.Environmental epigenetics · 2026Article
- Associations between lifestyle, malnutrition, and health risks in a comprehensive population-based analysis.Scientific reports · 2025Article
- Latent profiles of emotional perceptions of ageing and health promotion lifestyle in older adults with diabetes: the mediating role of frailty.Journal of diabetes and metabolic disorders · 2025Article
- High exposure variance enables candidate biomarker detection in a small EWAS of methylmercury-exposed Peruvian adults.BMC genomic data · 2025Article
- Consumption of methyl donor nutrients and incidence of obesity: is the association influenced by parent's obesity? Results of 4 years of follow-up of the CUME study.International journal of obesity (2005) · 2025Article
- Article
- Folate-Associated DNA Methylation and Chemotherapy-Induced Toxicities in Patients With Colorectal Cancer.Molecular nutrition & food research · 2025Review
- DNA methylation signature of a lifestyle-based resilience index for cognitive health.Alzheimer's research & therapy · 2025Article
- Development and validation of an epigenetic signature of allostatic load.Bioscience reports · 2025Article
- Depression, Subjective Health, Obesity, and Multimorbidity are Associated with Epigenetic Age Acceleration.Journal of biomedical and life sciences · 2025Article
- A comprehensive lifestyle index and its associations with DNA methylation and type 2 diabetes among Ghanaian adults: the rodam study.Clinical epigenetics · 2024Article
- Impact of combined exercise on blood DNA methylation and physical health in older women with obesity.PloS one · 2024Article
- Blood-based genome-wide DNA methylation correlations across body-fat- and adiposity-related biochemical traits.American journal of human genetics · 2023Article
- miR-205-5p inhibits homocysteine-induced pulmonary microvascular endothelium dysfunction by targeting FOXO1.Acta biochimica et biophysica Sinica · 2023Article
- Review
- Implication of DNA methylation during lifestyle mediated weight loss.Frontiers in endocrinology · 2023Review
- DNA methylation patterns reflect individual's lifestyle independent of obesity.Clinical and translational medicine · 2022Article
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveObesity is driven by modifiable lifestyle factors whose effects may be mediated by epigenetics. Therefore, we investigated lifestyle effects on blood DNA methylation in participants of the LIFE-Adult study, a well-characterised population-based cohort from Germany. RESEARCH DESIGN AND
methodsLifestyle scores (LS) based on diet, physical activity, smoking and alcohol intake were calculated in 4107 participants of the LIFE-Adult study. Fifty subjects with an extremely healthy lifestyle and 50 with an extremely unhealthy lifestyle (5th and 95th percentiles LS) were selected for genome-wide DNA methylation analysis in blood samples employing Illumina Infinium® Methylation EPIC BeadChip system technology.
resultsDifferences in DNA methylation patterns between body mass index groups (<25 vs. >30 kg/m
conclusionsDNA methylation patterns help discriminate individuals with a healthy versus unhealthy lifestyle, which may mask subtle methylation differences derived from obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.