Evidence map›Paper›PMID 35692081›Full record

ArticleJournal of clinical laboratory analysis2022

Predictive value of the apolipoprotein B/A1 ratio in intracerebral hemorrhage outcomes.

Rasha Alsamani, Zhang Limin, Wu Jianwei, Wang Dan, Sun Yuehong, Liu Ziwei, Xu Huiwen, Wang Dongzhi, Shi Yijun, Qian Lingye and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Rasha AlsamaniDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0001-6175-4699
Zhang LiminDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wu JianweiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wang DanDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Sun YuehongDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Liu ZiweiDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xu HuiwenDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wang DongzhiDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shi YijunDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Qian LingyeDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhao XingquanDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhang GuojunDepartment of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CN

Funding

Beijing Hospital Authority Clinical Medicine Development of Special Funding ZYLX202108Capital Medical University PYZ2017067
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe apolipoprotein B (apoB)/apolipoprotein A1 (apoA1) ratio is a key indicator in predicting future cardiovascular outcomes. However, it is still unclear whether the ratio of apoB/apoA1 is a better predictor of the outcomes after intracerebral hemorrhage (ICH). Therefore, we aimed to assess the relationships between the ratio of apoB/apoA1 and functional outcomes, all-cause mortality, and stroke recurrence in ICH patients.

methodsTwo hundred and sixteen Chinese ICH patients participated in this study from December 2018 to December 2019. Laboratory routine tests including hematology analysis, coagulation tests, and lipid levels were examined. The clinical outcomes included functional outcomes evaluated by the modified Rankin Scale score (mRS), all-cause death, and stroke recurrence 1 year after discharge. Associations between the apoB/apoA1 ratio and the outcomes were evaluated using logistic regression analysis. Based on multivariate analysis, we constructed a nomogram. Univariate survival analysis was performed by the Kaplan-Meier method and log-rank test. All the patients were classified into two groups by the median value of the apoB/apoA1 ratio: B1 < 0.8 and B2 ≥ 0.8.

resultsOf the 216 patients, 107 had an apoB/apoA1 ratio ≥ 0.8. Eighty-five patients had poor functional outcomes (mRS ≥ 3), and 32 patients had severe functional outcomes (mRS ≥ 4). During the 1-year follow-up, a total of 18 patients died, and 13 patients had apoB/apoA1 ratio levels ≥0.8 during the 1-year follow-up period. Moreover, 16 recurrent strokes were recorded. Adjustments for age, sex, smoking, alcohol, body mass index, lipid levels, and hematoma site and volume showed that a high apoB/apoA1 ratio was significantly related to adverse functional outcomes and all-cause mortality. The ORs for B2 versus B1 were 3.76 (95% CI: 1.37 to 10.40, p = 0.010), 22.74 (95% CI: 1.08 to 474.65, p = 0.044), and 7.23 (95% CI: 1.28 to 40.88, p = 0.025) for poor functional outcomes with mRS ≥ 3, mRS ≥ 4, and all-cause mortality, respectively.

conclusionAn increased apoB/apoA1 ratio at admission was independently related to poor functional outcome and all-cause mortality in ICH patients at the 1-year follow-up.

Indexed as

Apolipoproteins BStrokeApolipoprotein A-IAsian PeopleCerebral HemorrhageHumansApolipoprotein A-IApolipoproteins BapoB/apoA1 ratiointracerebral hemorrhagemortalityoutcome

Identifiers

PMID35692081
PMCPMC9279969
OpenAlexW4282827205

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.