Evidence map›Paper›PMID 35692052›Full record

ReviewNeurological research and practice2022

Antiplatelets or anticoagulants? Secondary prevention in cervical artery dissection: an updated meta-analysis.

Ei Zune The, Ne Naing Lin, Ching Jocelyn Chan, Jason Cher Wei Loon, Benjamin Yong-Qiang Tan, Chee Seong Raymond Seet, Hock Luen Teoh, Joy Vijayan, Leong Litt Leonard Yeo

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurological research and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Ei Zune TheDivision of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore. eizune.the@nhs.net.ORCID http://orcid.org/0000-0002-2367-7685
Ne Naing LinUniversity of Medicine 1, Yangon, Myanmar.
Ching Jocelyn ChanNational University of Singapore, Singapore, Singapore.
Jason Cher Wei LoonNational University of Singapore, Singapore, Singapore.
Benjamin Yong-Qiang TanDivision of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore.
Chee Seong Raymond SeetDivision of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore.
Hock Luen TeohDivision of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore.
Joy VijayanDivision of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore.
Leong Litt Leonard YeoDivision of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore.
National University Hospital · SGNational University of Singapore · SGLeicester General Hospital · GBUniversity Of Medicine 1 Yangon · MM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtracranial artery dissection involving either internal carotid artery or vertebral artery is a major cause of stroke in adults under 50 years of age. There is no conclusive evidence whether antiplatelets or anticoagulants are better suited in the treatment of extracranial artery dissection.

objectivesTo determine whether antiplatelets or anticoagulants have advantage over the other in the treatment of extracranial artery dissection for secondary prevention of recurrent ischemic events or death.

methodsPresent meta-analysis followed Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 statement. Database search was done in Medline, Cochrane Central Register of Controlled Trials (CENTRAL) and ClinicalTrials.gov from inception to May 2021 using pre-defined search strategy. Additional studies were identified from reference lists from included studies, reviews and previous meta-analyses. Outcome measures were ischaemic stroke, ischaemic stroke or transient ischaemic attack (TIA), and death.

resultsTwo RCTs and 64 observational studies were included in the meta-analysis. While the outcome measures of stroke, stroke or TIA and death were numerically higher with antiplatelet use, there were no statistically significant differences between antiplatelets and anticoagulants.

conclusionWe found no significant difference between antiplatelet and anticoagulation treatment after extracranial artery dissection. The choice of treatment should be tailored to individual cases.

Indexed as

AnticoagulantsAspirinExtracranial artery dissectionInternal carotid arteryMeta-analysisSecondary preventionStrokeVertebral artery

Identifiers

PMID35692052
PMCPMC9190132
OpenAlexW4282556084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.