ArticleMolecular psychiatry2022
Augmented pain inhibition and higher integration of pain modulatory brain networks in women with self-injury behavior.
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Offset Analgesia and Onset Hyperalgesia: A Comparison Between Women With Non-Suicidal Self-Injury and Healthy Women.Brain and behavior · 2026Article
- [Research progress on influencing factors and biological mechanisms of non-suicidal self-injury in children and adolescents].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- A multidimensional examination of pain threshold and non-suicidal self-injury: psychological and physiological determinants in adolescents.BJPsych open · 2026Article
- Assessing the prevalence, characteristics and psychosocial correlates of nonsuicidal self-injury among Vietnamese adolescent psychiatric outpatients: a cross-sectional study.Frontiers in psychiatry · 2026Article
- Genetic and environmental aetiologies of the transition from nonsuicidal self-injury to suicide attempt: a longitudinal twin study.Molecular psychiatry · 2025Article
- Neural mechanisms and neuromodulation therapies for non-suicidal self-injury.Molecular psychiatry · 2025Review
- Network of cognitive, emotional, and pain perception factors linked to non-suicidal self-injury in Chinese adolescents.BMC psychology · 2025Article
- Attenuation of Self-Induced Pain in Women With Nonsuicidal Self-Injury and Healthy Controls.European journal of pain (London, England) · 2025Article
- Article
- Short-term effects of transcranial direct current stimulation on pain sensitivity, emotional and cognitive processes in non-suicidal self-injury: a randomised controlled trial.General psychiatry · 2025Article
- Common neural correlates of disgust processing in childhood maltreatment and peer victimisation.BJPsych open · 2024Article
- Effects of Apnea-Induced Hypoxia on Hypoalgesia in Healthy Subjects.Sports (Basel, Switzerland) · 2024Article
- Acute, Chronic, and Everyday Physical Pain in Borderline Personality Disorder.Current psychiatry reports · 2024Review
- Using decision tree to predict non-suicidal self-injury among young adults: the role of depression, childhood maltreatment and recent bullying victimization.European journal of psychotraumatology · 2024Article
- Research on prediction model of adolescent suicide and self-injury behavior based on machine learning algorithm.Frontiers in psychiatry · 2024Article
- Potential mechanisms of non-suicidal self-injury (NSSI) in major depressive disorder: a systematic review.General psychiatry · 2023Article
- Increased Incidence of Upper Extremity Soft Tissue Injuries and Orthopaedic Surgeries in Patients with Eating Disorders.The Iowa orthopaedic journal · 2023Article
- Modeling and controlling the body in maladaptive ways: an active inference perspective on non-suicidal self-injury behaviors.Neuroscience of consciousness · 2023Article
- A Theoretical Endogenous Opioid Neurobiological Framework for Co-occurring Pain, Trauma, and Non-suicidal Self-injury.Current pain and headache reports · 2022Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals who engage in nonsuicidal self-injury (NSSI) have demonstrated insensitivity to pain compared with individuals without NSSI. Yet, the neural mechanisms behind this difference are unknown. The objective of the present study was to determine which aspects of the pain regulatory system that account for this decreased sensitivity to pain. In a case-control design, 81 women, aged 18-35 (mean [SD] age, 23.4 [3.9]), were included (41 with NSSI and 40 healthy controls). A quantitative sensory testing protocol, including heat pain thresholds, heat pain tolerance, pressure pain thresholds, conditioned pain modulation (assessing central down-regulation of pain), and temporal summation (assessing facilitation of pain signals) was used. Pain-evoked brain responses were assessed by means of fMRI scanning during thermal pain. NSSI participants showed a more effective central down-regulation of pain, compared to controls, assessed with conditioned pain modulation. The neural responses to painful stimulation revealed a stronger relation between nociceptive and pain modulatory brain regions in NSSI compared to controls. In line with previous studies, pressure and heat pain thresholds were higher in participants with NSSI, however, there were no correlations between pain outcomes and NSSI clinical characteristics. The augmented pain inhibition and higher involvement of pain modulatory brain networks in NSSI may represent a pain insensitive endophenotype associated with a greater risk for developing self-injurious behavior.
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