Evidence map›Paper›PMID 35691953›Full record

ArticleAnnals of surgical oncology2022

Impact of Preoperative CEA Uptrend on Survival Outcomes in Patients with Colorectal Liver Metastasis After Hepatectomy.

Yutaro Hori, Satoru Seo, Tomoaki Yoh, Kentaro Ueno, Koshiro Morino, Rei Toda, Takahiro Nishio, Yukinori Koyama, Ken Fukumitsu, Takamichi Ishii and 4 more

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Article in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Yutaro HoriDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Satoru SeoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. rutosa@kuhp.kyoto-u.ac.jp.
Tomoaki YohDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kentaro UenoDepartment of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Koshiro MorinoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Rei TodaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takahiro NishioDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yukinori KoyamaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ken FukumitsuDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takamichi IshiiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Koichiro HataDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Toshihiko MasuiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kojiro TauraDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Etsuro HatanoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreoperative carcinoembryonic antigen (CEA) has been reported as a prognostic factor in patients with colorectal liver metastasis (CRLM) after hepatectomy. However, the impact of a preoperative "CEA uptrend" on prognosis after hepatectomy in these patients remains unknown. This study assessed the impact of CEA uptrend on prognosis in patients undergoing hepatectomy for CRLM.

methodsConsecutive patients with CRLM who underwent hepatectomy between 2009 and 2018 were retrospectively analyzed. Patients with CRLM for whom CEA was measured both around 1 month before (CEA-1m) and within 3 days (CEA-3d) before hepatectomy were enrolled. A CEA-3d higher than both the upper limit of normal (5 ng/ml) and CEA-1m was defined as a CEA uptrend.

resultsStudy participants comprised 212 patients with CRLM. Of these, 88 patients (41.5%) showed a CEA uptrend. CEA uptrend indicated better discriminatory ability (corrected Akaike information criteria, 733.72) and homogeneity (likelihood ratio chi-square value, 18.80) than CEA-3d or CEA-1m. Patients with CEA uptrend showed poorer overall survival than those without CEA uptrend (p < 0.001). After adjusting for known prognostic factors, the prognostic significance of CEA uptrend retained (hazard ratio 2.63, 95% confidence interval 1.63-4.26, p < 0.001). In subgroup analyses, the prognostic significance of CEA uptrend was retained irrespective of the status of RAS mutation or response to preoperative chemotherapy.

conclusionsCEA uptrend offers better prediction of survival outcomes than conventional CEA measurements in patients undergoing hepatectomy for CRLM.

Indexed as

Colorectal NeoplasmsLiver NeoplasmsCarcinoembryonic AntigenHepatectomyHumansPrognosisRetrospective StudiesCarcinoembryonic Antigen

Identifiers

PMID35691953

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.