ReviewTrends in molecular medicine2022
Pathogenic associations between oral and gastrointestinal diseases.
Review in Trends in molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Apical periodontitis in inflammatory bowel disease: a meta-analysis at patient and tooth level.Frontiers in dental medicine · 2025Pooled it
- Elevated periodontal disease risk in ulcerative colitis patients: evidence from a comparative case-control study.Odontology · 2026Article
- Article
- Review
- [The Impact of Oral Microecology on the Development of Inflammatory Bowel Disease].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Article
- Multi-omics analysis identifies oxidative stress-related biomarkers and therapeutic targets linking periodontitis and ulcerative colitis via the oral-gut axis.Frontiers in immunology · 2026Article
- Periodontitis salivary microbiota exacerbates colitis by CXCL3 derived from gut microbiota-induced macrophages.Microbiome · 2025Article
- The impact of oral frailty and quality of life on gastrointestinal function in middle-aged and elderly patients: a cross-sectional study.Scientific reports · 2025Article
- Effect of cold atmospheric plasma on common oral pathogenic microorganisms: a narrative review.Annals of medicine · 2025Review
- Understanding the potential of probiotics in oral cancer prevention: a short review on microbial modulation.Discover oncology · 2025Review
- Impact of a removable prosthesis on chewing ability, quality of life, and patient satisfaction.Scientific reports · 2025Article
- Macrophage dynamics and the role of TREM2 at the oral mucosal barrier.Journal of translational medicine · 2025Article
- Special Issue: "Role of Extracellular Vesicles in Immunology".International journal of molecular sciences · 2025Article
- Article
- Association between oral health and bowel habits: a cross-sectional study.BMC public health · 2025Article
- Nanoparticles as Strategies for Modulating the Host's Response in Periodontitis Treatment.Nanomaterials (Basel, Switzerland) · 2025Review
- Article
- Microbiological mechanisms of oral mucosal disease: oral-intestinal crosstalk and probiotic therapy.Frontiers in oral health · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Both periodontitis and inflammatory bowel disease (IBD) are complex chronic conditions characterized by aberrant host immune response and dysregulated microbiota. Emerging data show an association between periodontitis and IBD, including direct and indirect mechanistic links between oral and intestinal inflammation. Direct pathways include translocation of proinflammatory microbes from the oral cavity to the gut and immune priming. Indirect pathways involve systemic immune activation with possible nonspecific effects on the gut. There are limited data on the effects of periodontal disease treatment on IBD course and vice versa, but early reports suggest that treatment of periodontitis decreases systemic immune activation and that treatment of IBD is associated with periodontitis healing, underscoring the importance of recognizing and treating both conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.