Evidence map›Paper›PMID 35691608›Full record

ArticleJournal of pharmaceutical sciences2022

A Full Target-Mediated Drug Disposition (TMDD) Model to Explain the Changes in Recombinant Human Erythropoietin (rhEpo) Pharmacokinetics in Patients with Different Bone Marrow Integrity Following Hematopoietic Transplantation.

Nan Wu, John A Widness, Xiaoyu Yan, Peter Veng-Pedersen, Guohua An

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nan WuDivision of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa city, Iowa, USA.
John A WidnessDepartment of Pediatrics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Xiaoyu YanSchool of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Peter Veng-PedersenDivision of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa city, Iowa, USA.
Guohua AnDivision of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, Iowa city, Iowa, USA. Electronic address: guohua-an@uiowa.edu.

Funding

THE RoLE OF NEONATAL ANEMIA IN LEARNING AND MEMORYP01HL046925 · NHLBI · UNIVERSITY OF IOWA · PI SOLA-VISNER, MARTHA C. · 1992 to 2022
$34.3M
NHLBI NIH HHS P01 HL046925
6 · The paper itself

Abstract

Our aim was to build a mechanistic full target-mediated drug disposition (TMDD) model for rhEpo to better understand rhEpo disposition, Epo receptor (EpoR) synthesis, and degradation in hematopoietic transplant patients with four distinct bone marrow conditions. All PK data were analyzed simultaneously using the nonlinear mixed effect modeling approach with NONMEM. The final model was a two-compartmental full TMDD model, which adequately characterizes rhEpo PK in patients and provides insight into the dynamics of free EpoR, rhEpo-EpoR, and total EpoR. The model predicted association rate constant (k

Indexed as

ErythropoietinHematopoietic Stem Cell TransplantationBone MarrowHumansReceptors, ErythropoietinRecombinant ProteinsErythropoietinReceptors, ErythropoietinRecombinant ProteinsPharmacokinetic/pharmacodynamic (PK/PD) ModelingRecombinant human erythropoietin (rhEpo) Nonlinear pharmacokineticsTarget-mediated drug disposition (TMDD)

Identifiers

PMID35691608
PMCPMC9391296

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.