ArticleMolecular metabolism2022
Central NPFF signalling is critical in the regulation of glucose homeostasis.
Article in Molecular metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Displaced minds: ecologies of depression.Biomedical journal · 2026Article
- Neuropeptide FF receptor 2 overexpression aggravates lipid accumulation and metabolic dysfunction in mice with diet-induced metabolic stress.Biomedical journal · 2026Article
- Sex-Specific Role of NPVF Signalling in Homeostatic Control.Biomolecules · 2026Article
- Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis.Science advances · 2025Article
- Endurance training promotes the browning of WAT by enhancing the NPFF pathway in the hypothalamus in rats with type 2 diabetes.Iranian journal of basic medical sciences · 2025Article
- Deficiency of GPR10 and NPFFR2 receptors leads to sex-specific prediabetic syndrome and late-onset obesity in mice.Bioscience reports · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
objectiveNeuropeptide FF (NPFF) group peptides belong to the evolutionary conserved RF-amide peptide family. While they have been assigned a role as pain modulators, their roles in other aspects of physiology have received much less attention. NPFF peptides and their receptor NPFFR2 have strong and localized expression within the dorsal vagal complex that has emerged as the key centre for regulating glucose homeostasis. Therefore, we investigated the role of the NPFF system in the control of glucose metabolism and the histochemical and molecular identities of NPFF and NPFFR2 neurons.
methodsWe examined glucose metabolism in Npff
resultsLack of NPFF signalling in mice leads to improved glucose tolerance without significant impact on insulin excursion after the i.p. glucose challenge. In response to an i.p. bolus of insulin, Npff
conclusionsNPFF signalling plays an important role in the regulation of glucose metabolism. NPFF neurons in the SubP are likely to receive peripheral signals and mediate the control of whole-body glucose homeostasis via centrally vagal pathways. Targeting NPFF and NPFFR2 signalling may provide a new avenue for treating type 2 diabetes and obesity.
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