ArticleThe American journal of emergency medicine2022
Significance of digestive symptoms after COVID-19 vaccination: A retrospective single-center study.
Article in The American journal of emergency medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Association Between COVID-19 Vaccination and Gastrointestinal Manifestations: A Cross-Sectional Study.Health science reports · 2025Article
- Acute pancreatitis complicated with diabetic ketoacidosis following COVID-19 mRNA vaccination: a case report.Journal of rural medicine : JRM · 2024Article
- Questionnaire-based study of COVID-19 vaccination induced headache: evidence of clusters of adverse events.BMC neurology · 2024Article
- Investigating the association between the COVID-19 vaccination and incident gastrointestinal symptomology: A comprehensive dataset.Data in brief · 2023Article
- Severity of COVID-19 in Patients with Diarrhoea: A Systematic Review and Meta-Analysis.Tropical medicine and infectious disease · 2023Review
- Acute pancreatitis as an adverse effect of COVID-19 vaccination.SAGE open medical case reports · 2022Article
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThere is insufficient research on digestive symptoms and outcomes following coronavirus disease (COVID-19) vaccination. We aimed to investigate digestive symptoms and related complications among South Koreans who were administered COVID-19 vaccines.
methodsForty-six patients (men: 22, women: 24) with a median age of 68 years (interquartile range:55.5, 73.8 years) who experienced digestive symptoms following COVID-19 vaccination between March 1 and July 30, 2021, were included. This retrospective single-center study collected information on clinical symptoms, laboratory tests, imaging results, comorbidities, complications, treatment type, and prognosis.
resultsThirty-three (71.7%), nine (19.6%), and three (6.5%) patients were administered AZD1222 (AstraZeneca), BNT162b2 (Pfizer/BioNTech), and JNJ-78436735 (Johnson and Johnson) vaccines, respectively. Patients were classified with mild (25 patients, 54.3%), moderate (five patients, 10.9%), and severe (16 patients, 34.8%) based on disease severity. Digestive symptoms included abdominal pain, diarrhea, dyspepsia, and nausea, which usually developed within 1 day (78.3%) following the first vaccination. In total, 14 (30.4%) patients experienced only gastrointestinal symptoms, whereas 32 (69.6%) experienced non-gastrointestinal symptoms. Complications included enterocolitis (76%), acute kidney injury (9%), anaphylactoid reaction (2%), and duodenal perforation (2%).
conclusionsCOVID-19 vaccines caused digestive symptoms and other complications that ranged from mild to severe. While further validation is required, our results suggest that monitoring digestive symptoms following COVID-19 vaccination can help detect rather severe complications that require medical intervention.
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