Evidence map›Paper›PMID 35691161›Full record

ArticleJournal of photochemistry and photobiology. B, Biology2022

Evaluation of photosensitizer-containing superhydrophobic surfaces for the antibacterial treatment of periodontal biofilms.

Caroline Coradi Tonon, Shoaib Ashraf, Alessandra Nara de Souza Rastelli, Goutam Ghosh, Tayyaba Hasan, QianFeng Xu, Alexander Greer, Alan M Lyons

Open access · greenAbstract read
In one paragraph

Article in Journal of photochemistry and photobiology. B, Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. AirborneAdvanced healthcare materials · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Caroline Coradi TononWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, 40 Blossom St, Boston, MA 02114, United States.
Shoaib AshrafWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, 40 Blossom St, Boston, MA 02114, United States.
Alessandra Nara de Souza RastelliDepartment of Restorative Dentistry, School of Dentistry, Araraquara, São Paulo State University-UNESP, 1680 Humaitá St., Araraquara, SP 14801-903, Brazil.
Goutam GhoshSingletO(2) Therapeutics LLC, TechBox, Suite 3, 75 Clinton St, Staten Island, NY 10304, United States.
Tayyaba HasanWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, 40 Blossom St, Boston, MA 02114, United States; Division of Health Sciences and Technology, Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02139, United States.
QianFeng XuSingletO(2) Therapeutics LLC, TechBox, Suite 3, 75 Clinton St, Staten Island, NY 10304, United States.
Alexander GreerSingletO(2) Therapeutics LLC, TechBox, Suite 3, 75 Clinton St, Staten Island, NY 10304, United States; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, 365 Fifth Avenue, New York, NY 10016, United States; Department of Chemistry, Brooklyn College, City University of New York, Brooklyn, NY 11210, United States. Electronic address: greer@singletO2.com.
Alan M LyonsSingletO(2) Therapeutics LLC, TechBox, Suite 3, 75 Clinton St, Staten Island, NY 10304, United States; Department of Chemistry, College of Staten Island, City University of New York, Staten Island, New York 10314, United States; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, 365 Fifth Avenue, New York, NY 10016, United States. Electronic address: alan@singletO2.com.
Brooklyn College · USHarvard University · USMassachusetts General Hospital · USMassachusetts Institute of Technology · USThe Graduate Center, CUNY · USUniversidade Estadual Paulista (Unesp) · BR

Funding

3D-Printed Superhydrophobic-Tipped Optical Fiber for Targeted Periodontal Photodynamic TherapyR44DE026083 · NIDCR · SINGLETO2 THERAPEUTICS, LLC · PI XU, QIANFENG · 2019 to 2020
$1.5M
NIDCR NIH HHS R44 DE026083
6 · The paper itself

Abstract

Antimicrobial photodynamic therapy (aPDT) is a promising approach to control biofilms involved in periodontal diseases. However, certain challenges, such as staining of teeth, preferential interaction of photosensitizer (PS) with Gram-positive versus Gram-negative bacteria, and insufficient oxygen in hypoxic periodontal pockets have presented barriers to its use in the clinic. To overcome these challenges, a novel superhydrophobic (SH) film that generates airborne singlet oxygen has been developed. The SH-aPDT approach isolates the PS onto a topologically rough solid SH film on which channels allow air to diffuse to the PS surface, thus ensuring sufficient oxygen supply. Upon illumination, gas phase singlet oxygen (

Indexed as

PhotochemotherapyPhotosensitizing AgentsAnimalsAnti-Bacterial AgentsBiofilmsGram-Negative BacteriaGram-Positive BacteriaHydrophobic and Hydrophilic InteractionsOxygenSinglet OxygenAnti-Bacterial AgentsOxygenPhotosensitizing AgentsSinglet OxygenAntimicrobial photodynamic inactivationBacterial biofilmsChlorin e6Periodontal diseaseSinglet oxygenSuperhydrophobicity

Identifiers

PMID35691161
PMCPMC10373426
OpenAlexW4225143083

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.