Trial reportWorld journal of urology2022
Randomized prospective trial of the severity of irritative symptoms after HoLEP vs ThuFLEP.
Trial report in World journal of urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Efficacy and safety of thulium fiber laser versus conventional holmium:YAG laser in anatomical endoscopic enucleation of the prostate: a systematic review and pairwise meta-analysis.World journal of urology · 2026Pooled it
- "Defining the Drip: A Systematic Review of Incontinence Definitions and Predictors Following HoLEP".Current urology reports · 2025Pooled it
- The safety and efficacy of five surgical treatments in prostate enucleation: a network meta-analysis.BMC urology · 2024Pooled it
- Advances in lasers for the minimally invasive treatment of upper and lower urinary tract conditions: a systematic review.World journal of urology · 2023Pooled it
- Thulium fiber laser versus Holmium laser enucleation of the prostate: 24-month outcomes from a prospective randomized non-inferiority trial.World journal of urology · 2026Trial
- Thulium fiber laser versus holmium MOSESProstate cancer and prostatic diseases · 2026Trial
- Thulium fiber laser vs. holmium laser enucleation of the prostate: results of a prospective randomized non-inferiority trial.World journal of urology · 2024Trial
- Comparative Effectiveness and Safety of Thulium Laser Enucleation and Holmium Laser Enucleation for BPH: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2026Review
- Rates and Predictors of Persistent LUTS Medication Use After Laser Enucleation of the Prostate.Lower urinary tract symptoms · 2026Article
- HoLEP versus ThuFLEP: perioperative and functional outcomes in prostate enucleation.Lasers in medical science · 2026Article
- Article
- A comparative study of thulium fiber laser and holmium:YAG laser for prostate enucleation: a systematic review and meta-analysis.Journal of lasers in medical sciences · 2026Review
- Thulium fiber laser enucleation of the prostate with SOLTIVE™ SuperPulsed laser systems: a prospective evaluation of early outcomes in an Asian cohort.Frontiers in urology · 2026Article
- Thulium fiber laser enucleation of the prostate (ThuFLEP) for the treatment of benign prostatic obstruction: a comparative study of men with prostate volumes ≥ 150 mL and < 150 mL.World journal of urology · 2025Article
- HoLEP versus ThuFLEP in men with very large prostates (> 175 ml).World journal of urology · 2025Article
- A Comparison of the First 60 Enucleation Cases Using a Thulium Fiber Laser without a Mentor to a Transurethral Resection of the Prostate (TURP) and Open Prostatectomy, and the Learning Curve.Medicina (Kaunas, Lithuania) · 2024Article
- Evaluation of the learning curve for Thulium fiber laser enucleation of prostate (ThuFLEP): retrospective study of a single-surgeon experience in real-world settings.World journal of urology · 2024Article
- Comparison of the effects of Ho: YAG laser virtual Basket™ pulse modulation and Thulium fiber laser on kidney tissue - an ex vivo experimental study.Lasers in medical science · 2024Article
- Comparison of HoLEP, ThuLEP and ThuFLEP in the treatment of benign prostatic obstruction: a propensity score-matched analysis.World journal of urology · 2024Article
- Thulium fiber laser vs. holmium laser enucleation of the prostate: results of a prospective randomized non-inferiority trial.World journal of urology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the short-term postoperative functional outcomes and severity of irritative symptoms following holmium and thulium fiber laser enucleation (HoLEP and ThuFLEP).
methodsThis prospective randomized single-blinded study was performed in accordance with CONSORT. The inclusion criteria were IPSS > 20 or Qmax < 10 ml/s. Patients were randomized between HoLEP and ThuFLEP. Demographics, objective data (PSA, prostate volume, etc.), data on urinary and sexual function (IPSS, IIEF, QoL, QUID, Qmax, ICIQ-MLUTS) were collected. Detailed perioperative information and postoperative data on functional outcomes at 1, 2, 3, 4, 6, 8, 10, 12 weeks and 6 months were collected.
resultsData on 163 participants were included (77-HoLEP, 86-ThuFLEP). No differences were found in surgery duration; number of postoperative complications (Clavien-Dindo I-III), catheterization time and hospital stay. Functional outcomes up to 6 months didn't differ between the groups (IPPS, IIEF, QoL, QUID, ICIQ-MLUTS, Qmax, p > 0.05). Total ICIQ-MLUTS, bother and voiding scores at 1 and 3 months significantly increased compared with the baseline in both groups (p < 0.05). No difference between the groups were observed. In HoLEP the SUI series rate was 1.3% and 1.3% after 3 and 6 months following the procedure; in ThuFLEP: it was 3.5% and 2.3% respectively (p = 0.35 and p = 0.54).
conclusionThe preliminary results of the study showed no apparent differences in functional outcomes (IPSS, Qmax), rate of SUI or irritative symptoms. Both ThuFLEP and HoLEP are efficient ways of treating benign prostatic obstruction. Both surgeries are comparable in terms of duration and postoperative complication rates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.