ArticleScientific reports2022
Reduced arterial elasticity after anabolic-androgenic steroid use in young adult males and mice.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Enhanced games and performance-optimized athletes: anticipating the orthopedic challenges, a narrative review.Acta orthopaedica et traumatologica turcica · 2026Review
- Metandienone abuse induces hepatotoxicity via dysregulated inflammation and metabolic dysfunction.The Journal of international medical research · 2026Article
- Testosterone-Induced Heart Failure in a Professional Dancer.JACC. Case reports · 2026Article
- Preventing Atherosclerotic Cardiovascular Disease in Young Male Androgen Abusers.Clinical cardiology · 2026Review
- Anabolic-Androgenic Steroids Induced Cardiomyopathy: A Narrative Review of the Literature.Biomedicines · 2025Review
- Article
- Impaired vascular function among young users of anabolic-androgenic steroids.Scientific reports · 2024Article
- Clustering psychopathology in male anabolic-androgenic steroid users and nonusing weightlifters.Brain and behavior · 2023Article
- Health service engagement, side effects and concerns among men with anabolic-androgenic steroid use: a cross-sectional Norwegian study.Substance abuse treatment, prevention, and policy · 2023Article
- Ischemic Stroke in the Setting of Anabolic Androgenic Steroid Use.Kansas journal of medicine · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-doses of anabolic-androgenic steroids (AAS) is efficient for building muscle mass, but pose a risk of cardiovascular side effects. Little is known of the effect of AAS on vasculature, but previous findings suggest unfavorable alterations in vessel walls and vasoreactivity. Here, long-term effect of AAS on vascular function and morphology were examined in male weightlifters, and in a mimicking animal model. Arterial elasticity and morphology were tested with ultrasound, pulse wave velocity (PWV) and carotid intima media thickness (cIMT) in 56 current male AAS users, and 67 non-exposed weightlifting controls (WLC). Female mice were treated with testosterone for 14 days and echocardiography were applied to evaluate vascular function and morphology. Male AAS users had higher PWV (p = 0.044), reduced carotid artery compliance (p = 0.0005), and increased cIMT (p = 0.041) compared to WLC. Similar functional changes were found in the ascending aorta of mice after 7- (p = 0.043) and 14 days (p = 0.001) of testosterone treatment. This animal model can be used to map molecular mechanisms responsible for complications related to AAS misuse. Considering the age-independent stiffening of major arteries and the predictive power of an increase in PWV and cIMT, the long-term users of AAS are at increased risk of severe cardiovascular events.
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