ArticleScientific reports2022
Mechanical loading of cranial joints minimizes the craniofacial phenotype in Crouzon syndrome.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Regional variability in craniofacial stiffness: a study in normal and Crouzon mice during postnatal development.Biomechanics and modeling in mechanobiology · 2025Article
- Cyclic loading failed to promote growth in a pig model of midfacial hypoplasia.Journal of anatomy · 2024Article
- Article
- Secondary metopic craniosynostosis after posterior cranial decompression in cloverleaf skull deformity.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Functional adaptation of the infant craniofacial system to mechanical loadings arising from masticatory forces.Proceedings. Biological sciences · 2024Article
- The biomechanics of chewing and suckling in the infant: A potential mechanism for physiologic metopic suture closure.PLoS computational biology · 2023Article
- Synchondrosis fusion contributes to the progression of postnatal craniofacial dysmorphology in syndromic craniosynostosis.Journal of anatomy · 2023Article
- Cranium growth, patterning and homeostasis.Development (Cambridge, England) · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Children with syndromic forms of craniosynostosis undergo a plethora of surgical interventions to resolve the clinical features caused by the premature fusion of cranial sutures. While surgical correction is reliable, the need for repeated rounds of invasive treatment puts a heavy burden on the child and their family. This study explores a non-surgical alternative using mechanical loading of the cranial joints to prevent or delay craniofacial phenotypes associated with Crouzon syndrome. We treated Crouzon syndrome mice before the onset of craniosynostosis by cyclical mechanical loading of cranial joints using a custom designed set-up. Cranial loading applied to the frontal bone partially restores normal skull morphology, significantly reducing the typical brachycephalic appearance. This is underpinned by the delayed closure of the coronal suture and of the intersphenoidal synchondrosis. This study provides a novel treatment alternative for syndromic craniosynostosis which has the potential to be an important step towards replacing, reducing or refining the surgical treatment of all craniosynostosis patients.
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