ArticleNature communications2022
Structural basis of resistance to herbicides that target acetohydroxyacid synthase.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- Pro-197 mutations confer resistance to thiencarbazone but not to foramsulfuron in ALS-resistant Poa annua populations.Pest management science · 2026Article
- Isoform-specific function underlies differential herbicide resistance of the W574L mutation in peanut AhALS isozymes.Pest management science · 2026Article
- Design and evolution of the tetracycline repressor into sulfonylurea herbicide-responsive gene switches for field crops.Nature communications · 2026Article
- Establishment of a versatile virus-based system for elucidating herbicide resistance in Galium aparine.Plant physiology · 2026Article
- Synthesis and Herbicidal Activity of NovelMolecules (Basel, Switzerland) · 2026Article
- Chromosome-level genome assembly of triploid Cyperus rotundus uncovers allelic expression patterns and herbicide resistance mechanisms.Plant communications · 2026Article
- AHAS structural changes caused by mutations result in differences in binding affinity and resistance to two herbicides inFrontiers in plant science · 2026Article
- Stacked mutations in multi-copy AHAS genes enhance sulfonylurea herbicide resistance in soybean.The Plant journal : for cell and molecular biology · 2025Article
- Substrate-based discovery of α-hydroxycarboxylic acid derivatives as potential herbicides targeting dihydroxyacid dehydratase.Nature communications · 2025Article
- Arabidopsis as a model for translational research.The Plant cell · 2025Review
- Genetic characterization of the AHAS mutant line K4 with resistance to AHAS-inhibitor herbicides in rapeseed (Brassica napus L.).Stress biology · 2025Article
- An easy and sensitive assay for acetohydroxyacid synthases based on the simultaneous detection of substrates and products in a single step.Analytical and bioanalytical chemistry · 2024Article
- Current status of community resources and priorities for weed genomics research.Genome biology · 2024Review
- Discovery of a New Class of Lipophilic Pyrimidine-Biphenyl Herbicides Using an Integrated Experimental-Computational Approach.Molecules (Basel, Switzerland) · 2024Article
- A Double Mutation in thePlants (Basel, Switzerland) · 2023Article
- Crystal structures of herbicide-detoxifying esterase reveal a lid loop affecting substrate binding and activity.Nature communications · 2023Article
- Degradation of PET Bottles by an EngineeredPolymers · 2023Article
- A LuALS Mutation with High Sulfonylurea Herbicide Resistance inInternational journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetohydroxyacid synthase (AHAS) is the target for more than 50 commercial herbicides; first applied to crops in the 1980s. Since then, 197 site-of-action resistance isolates have been identified in weeds, with mutations at P197 and W574 the most prevalent. Consequently, AHAS is at risk of not being a useful target for crop protection. To develop new herbicides, a functional understanding to explain the effect these mutations have on activity is required. Here, we show that these mutations can have two effects (i) to reduce binding affinity of the herbicides and (ii) to abolish time-dependent accumulative inhibition, critical to the exceptional effectiveness of this class of herbicide. In the two mutants, conformational changes occur resulting in a loss of accumulative inhibition by most herbicides. However, bispyribac, a bulky herbicide is able to counteract the detrimental effects of these mutations, explaining why no site-of-action resistance has yet been reported for this herbicide.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.