Evidence map›Paper›PMID 35690459›Full record

ReviewSeminars in pediatric surgery2022

Current understanding of Hirschsprung-associated enterocolitis: Pathogenesis, diagnosis and treatment.

Ruth A Lewit, Korah P Kuruvilla, Ming Fu, Ankush Gosain

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in pediatric surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Hirschsprung-associated enterocolitis: a comprehensive review.World journal of pediatric surgery · 2024
    Review
  13. Observational
  14. Hirschsprung disease.Nature reviews. Disease primers · 2023
    Review
  15. Article
  16. Review
  17. Who's talking to whom: microbiome-enteric nervous system interactions in early life.American journal of physiology. Gastrointestinal and liver physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ruth A LewitDivision of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center, 50 N. Dunlap Street, Suite 320, Memphis, TN 38105, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN, USA.
Korah P KuruvillaDivision of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center, 50 N. Dunlap Street, Suite 320, Memphis, TN 38105, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN, USA.
Ming FuDivision of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center, 50 N. Dunlap Street, Suite 320, Memphis, TN 38105, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN, USA.
Ankush GosainDivision of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center, 50 N. Dunlap Street, Suite 320, Memphis, TN 38105, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN, USA. Electronic address: agosain@uthsc.edu.
University of Tennessee Health Science Center · USLe Bonheur Children's Hospital · US

Funding

Role of microbial-modulated bile acid receptor signaling in breast cancerR01CA253329 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Katherine Loree Cook, Liza Makowski-Hayes · 2020 to 2026
$3.0M
Dysbiosis in Hirschsprung Associated Enterocolitis PathogenesisR01DK125047 · NIDDK · UNIVERSITY OF VIRGINIA · PI GOSAIN, ANKUSH · 2020 to 2024
$2.1M
Modeling Host-Fungal Interactions in Hirschsprung-Associated EnterocolitisR21AI163503 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI GOSAIN, ANKUSH, PIERRE, JOSEPH F · 2021 to 2022
$441k
NCI NIH HHS R01 CA253329NIAID NIH HHS R21 AI163503NIDDK NIH HHS R01 DK125047
6 · The paper itself

Abstract

Hirschsprung-associated enterocolitis (HAEC) was described in 1886 by Harald Hirschsprung and is a potentially deadly complication of Hirschsprung Disease. HAEC is classically characterized by abdominal distension, fever, and diarrhea, although there can be a variety of other associated symptoms, including colicky abdominal pain, lethargy, and the passage of blood-stained stools. HAEC occurs both pre-operatively and post-operatively, is the presenting symptom of HSCR in up to 25% of infants and varies in overall incidence from 20 to 60%. This article reviews our current understanding of HAEC pathogenesis, diagnosis, and treatment with discussion of areas of ongoing research, controversy, and future investigation.

Indexed as

EnterocolitisHirschsprung DiseaseHumansInfantDysmotilityEnterocolitisHirschsprung diseaseMicrobiomeMucosal immunityTreatment

Identifiers

PMID35690459
PMCPMC9523686
OpenAlexW4224291697

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.