Evidence map›Paper›PMID 35690388›Full record

Trial reportBrain stimulation

Self-administered transcranial direct current stimulation for pain in older adults with knee osteoarthritis: A randomized controlled study.

Geraldine Martorella, Kenneth Mathis, Hongyu Miao, Duo Wang, Lindsey Park, Hyochol Ahn

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04016272 (Self-Administered Transcranial Direct Current Stimulation for Pain in Older Adults With Knee Osteoarthritis), which is not on this map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04016272 nacompletednot on this map

Self-Administered Transcranial Direct Current Stimulation for Pain in Older Adults With Knee Osteoarthritis: A Phase II Randomized Sham-Controlled Trial

TypeinterventionalSponsorFlorida State UniversityRan2019 to 2021Enrolled123ConditionsOsteo Arthritis KneeArmsActive tDCS, Sham tDCS
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Geraldine MartorellaFlorida State University College of Nursing, Tallahassee, FL, USA.
Kenneth MathisThe University of Texas Health Science Center School of Medicine at Houston, Houston, TX, USA.
Hongyu MiaoFlorida State University College of Nursing, Tallahassee, FL, USA.
Duo WangFlorida State University Department of Statistics, Tallahassee, FL, USA.
Lindsey ParkFlorida State University College of Nursing, Tallahassee, FL, USA.
Hyochol AhnFlorida State University College of Nursing, Tallahassee, FL, USA. Electronic address: hahn@fsu.edu.
Florida State University · USThe University of Texas Health Science Center at Houston · US

Funding

Pain-related Brain Mechanisms for Pain Catastrophizing Behavior in Response to Home-based Mindfulness-based Meditation Paired with Transcranial Direct Current StimulationR01NR019051 · NINR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI AHN, HYOCHOL · 2020 to 2025
$2.9M
Self-Administered Transcranial Direct Current Stimulation for Pain in Older Adults with Knee Osteoarthritis: A Phase II Randomized Sham-Controlled TrialR15NR018050 · NINR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MATHIS, KENNETH B · 2019 to 2020
$618k
NINR NIH HHS R01 NR019051NINR NIH HHS R15 NR018050
6 · The paper itself

Abstract

backgroundKnee osteoarthritis (OA) is a leading cause of pain in older adults. Previous studies indicated clinic-based transcranial direct current stimulation (tDCS) was effective to reduce pain in various populations, but no published studies have reported the efficacy of home-based self-administered tDCS in older adults with knee OA using a randomized clinical study.

objectiveThe purpose of this study was to evaluate the efficacy and feasibility of tDCS on clinical pain intensity in adults with knee OA pain.

methodsOne hundred twenty participants aged 50-85 years with knee OA pain were randomly assigned to receive fifteen daily sessions of 2 mA tDCS for 20 min (n = 60) or sham tDCS (n = 60) over 3 weeks with remote supervision via telehealth. Clinical pain intensity was measured by the Numeric Rating Scale and Western Ontario and McMaster Universities Osteoarthritis Index. Also, we collected data on the tDCS experience via a questionnaire.

resultsParticipants (68% female) had a mean age of 66 years. Active tDCS significantly reduced pain intensity compared to sham tDCS after completion of the fifteen daily sessions (Cohen's d = 1.20; p-value < 0.0001). Participants showed high levels of satisfaction with their tDCS experience, and there have been no adverse events.

conclusionWe demonstrated that home-based self-administered tDCS was feasible and reduced clinical pain intensity in older adults with knee OA, which can increase its accessibility. Future studies with multi-site randomized controlled trials are needed to validate our findings.

trial registrationClinicalTrials.gov Identifier NCT04016272.

Indexed as

Osteoarthritis, KneeTranscranial Direct Current StimulationAgedFemaleHumansMalePainPain ManagementPain MeasurementTreatment OutcomeAcceptabilityEfficacyFeasibilityKnee osteoarthritisPainTranscranial direct current stimulation

Identifiers

PMID35690388
PMCPMC9387776
OpenAlexW4281662817

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.