Reading oscillatory instructions: How cells achieve time-dependent responses to oscillating transcription factors.

Veena Venkatachalam, Ashwini Jambhekar, Galit Lahav

Abstract readReview

In one paragraph

Review in Current opinion in cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Chronic low-dose of BPS and PFOS alter adipogenic programming and impair insulin responsiveness in human adipocytes.Journal of endocrinological investigation · 2026
Article
Body-wide synchronization of insulin-signaling dependent DAF-16/FOXO nuclear translocation pulses correlated with C. elegans growth.Nature communications · 2025
Article
The advantage of periodic over constant signalling in microRNA-mediated regulation.Nucleic acids research · 2025
Article
Multiscale information processing in the immune system.Frontiers in immunology · 2025
Review
An oscillating reaction network with an exact closed form solution in the time domain.BMC bioinformatics · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Veena VenkatachalamDepartment of Systems Biology, Blavatnik Institute at Harvard Medical School, 210 Longwood Avenue, Boston, MA 02115, USA; Department of Radiation Oncology, Dana-Farber Brigham Cancer Center, 75 Francis St, Boston, MA 02115, USA.

Ashwini JambhekarDepartment of Systems Biology, Blavatnik Institute at Harvard Medical School, 210 Longwood Avenue, Boston, MA 02115, USA; Ludwig Center at Harvard, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215, USA.

Galit LahavDepartment of Systems Biology, Blavatnik Institute at Harvard Medical School, 210 Longwood Avenue, Boston, MA 02115, USA; Ludwig Center at Harvard, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02215, USA. Electronic address: Galit@hms.harvard.edu.

Funding

Dynamics, Regulation and Function of p53 in Single CellsR35GM139572 · NIGMS · HARVARD MEDICAL SCHOOL · PI Galit Lahav · 2021 to 2026

$4.7M

NIGMS NIH HHS R35 GM139572

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Transcription FactorsTranscription Factors

Identifiers

PMID35690043

DOI10.1016/j.ceb.2022.102099

PMCPMC9533215

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.