ArticleSleep2022
Within-night repeatability and long-term consistency of sleep apnea endotypes: the Multi-Ethnic Study of Atherosclerosis and Osteoporotic Fractures in Men Study.
Article in Sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Cognitive behavioral therapy for insomnia is associated with reduced sleep apnea severity but not its endotype traits in those with comorbid insomnia and sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Trial
- The norepinephrine reuptake inhibitor reboxetine alone reduces obstructive sleep apnea severity: a double-blind, placebo-controlled, randomized crossover trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Trial
- Real-world generalizability of sleep apnea-related polysomnographic metrics and their associations with clinical comorbidities.Annals of the American Thoracic Society · 2026Article
- Distinguishing Age-specific Patterns in Comorbidities of Obstructive Sleep Apnea Using Real-World Data.medRxiv : the preprint server for health sciences · 2026Article
- Expert-level probabilistic breathing event detector informs phenotyping of sleep apnea.Nature communications · 2026Article
- Site of Collapse during Drug-induced Sleep Endoscopy Is Associated with Polysomnographic Endotypic Traits: An Observational Study.Annals of the American Thoracic Society · 2025Observational
- Research Priorities for Translating Endophenotyping of Adult Obstructive Sleep Apnea to the Clinic: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- Obstructive sleep apnea severity and pathophysiological traits in overlap syndrome: Insights from the SNOOzzzE cohort.Physiological reports · 2025Article
- Polysomnographic endotypes of successful multilevel upper airway surgery for obstructive sleep apnea.Sleep · 2025Article
- Editorial: Way to go with OSA biomarkers.Sleep · 2025Article
- Relationship between Symptom Profiles and Endotypes among Patients with Obstructive Sleep Apnea: A Latent Class Analysis.Annals of the American Thoracic Society · 2023Article
- Article
- Night-to-night reliability and agreement of physiological endotypes: two steps forward, one step back.Sleep · 2023Article
- Obstructive sleep apnoea heterogeneity and cardiovascular disease.Nature reviews. Cardiology · 2023Review
- Article
- Article
- Pathophysiology Underlying Demographic and Obesity Determinants of Sleep Apnea Severity.Annals of the American Thoracic Society · 2023Article
- Sleep apnea endotypes: from the physiological laboratory to scalable polysomnographic measures.Frontiers in sleep · 2023Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesObstructive sleep apnea (OSA) is characterized by multiple "endotypic traits," including pharyngeal collapsibility, muscle compensation, loop gain, and arousal threshold. Here, we examined (1) within-night repeatability, (2) long-term consistency, and (3) influences of body position and sleep state, of endotypic traits estimated from in-home polysomnography in mild-to-severe OSA (apnea-hypopnea index, AHI > 5 events/h).
methodsWithin-night repeatability was assessed using Multi-Ethnic Study of Atherosclerosis (MESA): Traits derived separately from "odd" and "even" 30-min periods were correlated and regression (error vs. N windows available) provided a recommended amount of data for acceptable repeatability (Rthreshold = 0.7). Long-term consistency was assessed using the Osteoporotic Fractures in Men Study (MrOS) at two time points 6.5 ± 0.7 years apart, before and after accounting for across-year body position and sleep state differences. Within-night dependence of traits on position and state (MESA plus MrOS data) was estimated using bootstrapping.
resultsWithin-night repeatability for traits ranged from R = 0.62-0.79 and improved to R = 0.69-0.83 when recommended amounts of data were available (20-35 7-min windows, available in 94%-98% of participants); repeatability was similar for collapsibility, loop gain, and arousal threshold (R = 0.79-0.83), but lower for compensation (R = 0.69). Long-term consistency was modest (R = 0.30-0.61) and improved (R = 0.36-0.63) after accounting for position and state differences. Position/state analysis revealed reduced loop gain in REM and reduced collapsibility in N3.
conclusionsEndotypic traits can be obtained with acceptable repeatability. Long-term consistency was modest but improved after accounting for position and state changes. These data support the use of endotypic assessments in large-scale epidemiological studies. CLINICAL TRIAL INFORMATION: The data used in the manuscript are from observational cohort studies and are not a part of the clinical trial.
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