Evidence map›Paper›PMID 35690009›Full record

ReviewCurrent opinion in virology2022

Gut virome in early life: origins and implications.

Elizabeth A Kennedy, Lori R Holtz

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Elizabeth A KennedyWashington University School of Medicine, Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, St. Louis, MO 63110, USA.
Lori R HoltzWashington University School of Medicine, Department of Pediatrics, St. Louis, MO 63110, USA. Electronic address: loriholtz@wustl.edu.

Funding

Enhancing the RADx Data Hub for Data FAIRnessOT2DB000009 · OD · STANFORD UNIVERSITY · PI MUSEN, MARK A · 2022 to 2023
$44.3M
Role of Environmental Exposures on the Infant Gut Bacterial Microbiome and ViromeR01DK122029 · NIDDK · WASHINGTON UNIVERSITY · PI HOLTZ, LORI R · 2020 to 2023
$2.4M
Dynamics and immune control of norovirus infection in neonatal miceF31AI167499 · NIAID · WASHINGTON UNIVERSITY · PI KENNEDY, ELIZABETH ALEXANDRA · 2022 to 2023
$38k
DB NIH HHS OT2 DB000009Doris Duke Charitable Foundation 2017076HRAO -2022-076NIAID NIH HHS F31 AI167499NIDDK NIH HHS R01 DK122029PKDF -839636TWCF -2021-20568
6 · The paper itself

Abstract

The human body is colonized by a multitude of bacteria, fungi, and viruses, which play important roles in health and disease. Microbial colonization during early life is thought to be a particularly important period with lasting consequences for health. Viral populations in the gut are particularly dynamic in early life before they stabilize in adulthood. The composition of the early-life virome is increasingly recognized as a determinant of disease later in life. Here, we review the development of the virome in healthy infants, as well as the role of the early-life virome in the development of disease states including diarrhea, malnutrition, and autoimmune diseases.

Indexed as

Gastrointestinal MicrobiomeVirusesAdultBacteriaHumansInfantVirome

Identifiers

PMID35690009
PMCPMC9575407

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.