Evidence map›Paper›PMID 35689808›Full record

ArticleEpilepsia2022

Predictive modeling of suicidal ideation in patients with epilepsy.

Matthew D Nemesure, Nicholas Streltzov, Lindsay M Schommer, Damien Lekkas, Nicholas C Jacobson, Krzysztof A Bujarski

Open access · greenAbstract read
In one paragraph

Article in Epilepsia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Matthew D NemesureCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA.ORCID 0000-0002-2369-600X
Nicholas StreltzovDartmouth-Hitchcock Medical Center Epilepsy Clinic, Lebanon, New Hampshire, USA.
Lindsay M SchommerDartmouth-Hitchcock Medical Center Epilepsy Clinic, Lebanon, New Hampshire, USA.ORCID 0000-0002-1549-0167
Damien LekkasCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA.
Nicholas C JacobsonCenter for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA.
Krzysztof A BujarskiDartmouth-Hitchcock Medical Center Epilepsy Clinic, Lebanon, New Hampshire, USA.ORCID 0000-0002-1329-5085
Dartmouth College · USDartmouth–Hitchcock Medical Center · US

Funding

Treatment Development & Evaluation CoreP30DA029926 · NIDA · DARTMOUTH COLLEGE · PI Lisa A. Marsch · 2011 to 2026
$21.5M
Training in the Science of Co-Occurring DisordersT32DA037202 · NIDA · DARTMOUTH COLLEGE · PI Lisa A. Marsch · 2014 to 2026
$4.7M
Personalized Deep Learning Models of Rapid Changes in Major Depressive Disorder Symptoms using Passive Sensor Data from Smartphones and Wearable DevicesR01MH123482 · NIMH · DARTMOUTH COLLEGE · PI JACOBSON, NICHOLAS CHARLES · 2020 to 2024
$2.6M
Neuromodulation of affective valence in humans by amygdala stimulationR21MH124674 · NIMH · DARTMOUTH-HITCHCOCK CLINIC · PI BUJARSKI, KRZYSZTOF · 2021 to 2022
$427k
NIDA NIH HHS P30 DA029926NIDA NIH HHS T32 DA037202NIMH NIH HHS R01 MH123482NIMH NIH HHS R21 MH124674
6 · The paper itself

Abstract

objectiveThe prevalence of suicide in the United States has seen an increasing trend and is responsible for 1.6% of all mortality nationwide. Although suicide has the potential to broadly impact the entire population, it has a substantially increased prevalence in persons with epilepsy (PWE), despite many of these individuals consistently seeing a health care provider. The goal of this work is to predict the development of suicidal ideation (SI) in PWE using machine learning methodology such that providers can be better prepared to address suicidality at visits where it is likely to be prominent.

methodsThe current study leverages data collected at an epilepsy clinic during patient visits to predict whether an individual will exhibit SI at their next visit. The data used for prediction consisted of patient responses to questions about the severity of their epilepsy, issues with memory/concentration, somatic problems, markers for mental health, and demographic information. A machine learning approach was then applied to predict whether an individual would display SI at their following visit using only data collected at the prior visit.

resultsThe modeling approach allowed for the successful prediction of an individual's passive and active SI severity at the following visit (r = .42, r = .39) as well as the presence of SI regardless of severity (area under the curve [AUC] = .82, AUC = .8). This shows that the model was successfully able to synthesize the unique combination of an individual's responses to important questions during a clinical visit and utilize that information to indicate whether that individual will exhibit SI at their next visit. SIGNIFICANCE: The results of this modeling approach allow the health care team to be prepared, in advance of a clinical visit, for the potential reporting of SI. By allowing the necessary support to be prepared ahead of time, it can be better integrated at the point of care, where patients are most likely to follow up on potential referrals or treatment.

Indexed as

EpilepsySuicideArea Under CurveHumansPrevalenceSuicidal IdeationUnited Statesepilepsymachine learningsuicidal ideation

Identifiers

PMID35689808
PMCPMC10129274
OpenAlexW4282943705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.