Evidence map›Paper›PMID 35689704›Full record

ArticlePediatric radiology2022

Chest computed tomography findings of ground-glass nodules with enhancing central vessel/nodule in pediatric patients with BMPR2 mutations and plexogenic arteriopathy.

Jason P Weinman, David A Mong, LaDonna J Malone, Dunbar D Ivy, Robin R Deterding, Csaba Galambos

Abstract read
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Article in Pediatric radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jason P WeinmanDepartment of Radiology, Children's Hospital Colorado, 13123 E. 16th Ave., Box 125, Aurora, CO, 80045, USA. jason.weinman@childrenscolorado.org.ORCID 0000-0001-6540-3757
David A MongDepartment of Radiology, Children's Hospital Colorado, 13123 E. 16th Ave., Box 125, Aurora, CO, 80045, USA.
LaDonna J MaloneDepartment of Radiology, Children's Hospital Colorado, 13123 E. 16th Ave., Box 125, Aurora, CO, 80045, USA.
Dunbar D IvyDivision of Cardiology, Department of Pediatrics, Children's Hospital Colorado, Aurora, CO, USA.
Robin R DeterdingDivision of Pulmonary Medicine, Department of Pediatrics, Children's Hospital Colorado, Aurora, CO, USA.
Csaba GalambosDepartment of Pathology and Laboratory Medicine, Children's Hospital Colorado, Aurora, CO, USA.
Children's Hospital Colorado · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGermline mutation in bone morphogenetic protein type II (BMPR2) is the most common cause of idiopathic/heritable pulmonary hypertension in pediatric patients. Despite the discovery of this gene there are no known descriptions of the CT or CT angiography findings in these children.

objectiveTo correlate the clinical presentation, pathology and chest CT findings in pediatric patients with pulmonary hypertension caused by mutations in the BMPR2 gene. MATERIALS AND

methodsWe performed a search to identify pediatric patients with a BMPR2 mutation and CT or CT angiography with the clinical history of pulmonary hypertension. Three pediatric radiologists reviewed the children's CT imaging findings and ranked the dominant findings in order of prevalence via consensus.

resultsWe identified three children with pulmonary hypertension and confirmed germline BMPR2 mutations, two of whom had undergone lung biopsy. We then correlated the imaging findings with histopathology and clinical course.

conclusionAll of our patients with BMPR2 mutations demonstrated a distinct CT pattern of ground-glass nodules with a prominent central enhancing vessel/nodule. These findings correlated well with the pathological findings of plexogenic arteriopathy.

Indexed as

Hypertension, PulmonaryBone Morphogenetic Protein Receptors, Type IIChildFamilial Primary Pulmonary HypertensionHumansMutationTomography, X-Ray ComputedBMPR2 protein, humanBone Morphogenetic Protein Receptors, Type IIBone morphogenetic protein type 2 receptor mutationChestChildrenComputed tomographyLungsPlexogenic arteriopathyPulmonary hypertension

Identifiers

PMID35689704
OpenAlexW4282917635

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.