ArticlePlant physiology2022
Small EPIDERMAL PATTERNING FACTOR-LIKE2 peptides regulate awn development in rice.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Comprehensive Profiling of the RicePlants (Basel, Switzerland) · 2026Article
- Plant Peptides on the Rise: From Historical Insight to Future Applications.Plant biotechnology journal · 2026Review
- To awn or not to awn: Revisiting the evolution of awnedness during rice domestication and improvement.Plant communications · 2026Review
- Telomere-to-telomere genome assembly and comprehensive mutation library facilitate bitter gourd breeding and functional genomics research.Plant communications · 2026Article
- Brachypodium SPEECHLESS2 Promoter Drives Expression of a Synthetic EPF to Reduce Stomatal Density in Sugarcane Without Pleiotropic Effects.Plant biotechnology journal · 2026Article
- From roots to reproduction: the multifaceted roles of rapid alkalinization factor and epidermal patterning factor peptides in plants.Journal of experimental botany · 2025Review
- Genetic analysis of the single internode dwarf 1 mutant in barley.BMC plant biology · 2025Article
- Comprehensive genome-wide identification and expression analysis of the EPF/EPFL gene family in oat.BMC genomics · 2025Article
- Harnessing neo-domestication of wild pigmented rice for enhanced nutrition and sustainable agriculture.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Competitive binding of small antagonistic peptides to the OsER1 receptor optimizes rice panicle architecture.Plant communications · 2025Article
- Peptide hormones in plants.Molecular horticulture · 2025Review
- Genetic dissection of foxtail millet bristles using combined QTL mapping and RNA-seq.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Pull the fuzes: Processing protein precursors to generate apoplastic danger signals for triggering plant immunity.Plant communications · 2024Review
- Investigation on the Potential Functions of ZmEPF/EPFL Family Members in Response to Abiotic Stress in Maize.International journal of molecular sciences · 2024Article
- Genome-wide analyses of member identification, expression pattern, and protein-protein interaction of EPF/EPFL gene family in Gossypium.BMC plant biology · 2024Article
- Genome wide association studies on seven yield-related traits of 183 rice varieties in Bangladesh.Plant direct · 2024Article
- Genome-wide identification and phylogenetic and expression pattern analyses of EPF/EPFL family genes in the Rye (Secale cereale L.).BMC genomics · 2024Article
- MADS1-regulated lemma and awn development benefits barley yield.Nature communications · 2024Article
- Genome-wide identification and expression analysis ofFrontiers in genetics · 2024Article
- Redefining awn development in rice through the breeding history of Japanese awn reduction.Frontiers in plant science · 2024Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The EPIDERMAL PATTERNING FACTOR (EPF) and EPF-LIKE (EPFL) family of small secreted peptides act to regulate many aspects of plant growth and development; however, their functions are not widely characterized in rice (Oryza sativa). Here, we used clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) technology to individually knockout each of 11 EPF/EPFL genes in the rice cultivar Kasalath. Loss of function of most OsEPF/EPFL genes generated no obvious phenotype alteration, while disruption of OsEPFL2 in Kasalath caused a short or no awn phenotype and reduced grain size. OsEPFL2 is strongly expressed in the young panicle, consistent with a role in regulating awn and grain development. Haplotype analysis indicated that OsEPFL2 can be classified into six major haplotypes. Nucleotide diversity and genetic differentiation analyses suggested that OsEPFL2 was positively selected during the domestication of rice. Our work to systematically investigate the function of EPF/EPFL peptides demonstrates that different members of the same gene family have been independently selected for their ability to regulate a similar biological function and provides perspective on rice domestication.
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