Evidence map›Paper›PMID 35689538›Full record

ArticleJournal of clinical laboratory analysis2022

Prognostic value of dynamic cardiac biomarkers in patients with acquired refractory thrombocytopenic purpura: A retrospective study in Chinese population.

Yinan Xu, Chengyuan Gu, Ruju Wang, Jiaqian Qi, Jun Wang, Tingbo Jiang, Min Jiang, Depei Wu, Tao You, Jianhong Fu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yinan XuHematological Intensive Care Unit，Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Chengyuan GuHematological Intensive Care Unit，Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Ruju WangHematological Intensive Care Unit，Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jiaqian QiHematological Intensive Care Unit，Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jun WangDepartment of Intensive Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.
Tingbo JiangDepartment of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Min JiangDepartment of Blood Transfusion, The First Affiliated Hospital of Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0001-6396-549X
Depei WuHematological Intensive Care Unit，Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Tao YouHematological Intensive Care Unit，Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0002-2333-8536
Jianhong FuHematological Intensive Care Unit，Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0002-9044-024X

Funding

Gusu Health Talents Programme GSWS2020006National Natural Science Foundation of China 81900140Open project of MOE Engineering Center of Hematological Disease of Soochow University SDGC2108Soochow University
6 · The paper itself

Abstract

introductionThrombotic thrombocytopenic purpura (TTP) is becoming a curable disease with the introduction of therapeutic plasma exchange (TPE). However, cardiovascular complications remain essential causes of mortality in patients with refractory TTP, while the association of cardiac biomarkers with the prognosis of TTP warrants further investigation.

methodsPatients admitted to the First Affiliated Hospital of Soochow University for refractory TTP from 2013 through 2020 were included in this retrospective study. Clinical characteristics were collected from electronic health records. Biomarker levels on admission and post TPE were recorded. Logistic regression was adopted to identify risk factors for mortality.

resultsA total of 78 patients with refractory TTP were included in this study. Twenty-one patients died during hospitalization, with a mortality rate of 26.9%. High-sensitivity cardiac troponin T (hs-cTnT), N-terminal probrain natriuretic peptide (NT-proBNP), and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ratios (AAR) were increased in deceased patients compared with the survival group. Multivariate analysis showed that AAR after TPE was associated with overall mortality (OR: 4.45, 95% CI 1.09-18.19). The areas under the receiver operator characteristic curve (AUC) of AAR, hs-cTnT, and NT-proBNP for the association with mortality were 0.814, 0.840, and 0.829, respectively.

conclusionHigher post-TPE cardiac biomarker levels are associated with increased in-hospital mortality in patients with refractory TTP.

Indexed as

Natriuretic Peptide, BrainPurpura, Thrombotic ThrombocytopenicBiomarkersChinaHumansPeptide FragmentsPrognosisRetrospective StudiesTroponin TBiomarkersNatriuretic Peptide, BrainPeptide FragmentsTroponin Taspartate transaminase/alanine transaminase ratiocardiac biomarkershigh-sensitivity cardiac troponin TN-terminal probrain natriuretic peptiderefractory thrombotic thrombocytopenic purpura

Identifiers

PMID35689538
PMCPMC9280007

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.