Evidence map›Paper›PMID 35689461›Full record

ArticleJournal of the American Geriatrics Society2022

AGS and NIA bench-to bedside conference summary: Cancer and cardiovascular disease.

Supriya Mohile, Caroline S Blaum, Peter M Abadir, William Dale, Daniel E Forman, Chunkit Fung, Holly M Holmes, Javid Moslehi, Karen M Mustian, Michael W Rich and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 1 country.

Supriya MohileDepartment of Medicine, University of Rochester Medical Center, Rochester, New York, United States.
Caroline S BlaumDepartment of Medicine, National Committee for Quality Assurance, Washington, District of Columbia, United States.
Peter M AbadirDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
William DaleDepartment of Supportive Care Medicine, City of Hope National Medical Center, Duarte, California, United States.
Daniel E FormanUniversity of Pittsburgh Department of Medicine, Pittsburgh Geriatric Research Education and Clinical Center, Pittsburgh, Pennsylvania, United States.
Chunkit FungDepartment of Medicine, University of Rochester Medical Center, Rochester, New York, United States.
Holly M HolmesUniversity of Texas, McGovern Medical School, Houston, Texas, United States.
Javid MoslehiDepartment of Medicine, University of California San Francisco, San Francisco, California, United States.
Karen M MustianDepartment of Medicine, University of Rochester Medical Center, Rochester, New York, United States.
Michael W RichDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States.
Heather E WhitsonDepartment of Medicine, Duke University, Durham, North Carolina, United States.
University of Rochester Medical Center · USCity Of Hope National Medical Center · USDurham VA Medical Center · USJohns Hopkins University · USNational Committee for Quality Assurance · USThe University of Texas Health Science Center at Houston · USUniversity of Pittsburgh · USUniversity of San Francisco · USWashington University in St. Louis · US

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Geriatric Oncology Research Infrastructure to Improve Clinical CareR33AG059206 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI WILLIAM DALE, Heidi Diana Klepin · 2020 to 2026
$5.1M
Immunologic and Antigenic Drivers of Immune Checkpoint Inhibitor-Associated MyocarditisR01HL156021 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Justin M Balko, Javid J Moslehi · 2021 to 2026
$4.9M
Novel mechanisms and predictors of VEGF receptor inhibitor-associated hypertensionR01HL141466 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MOSLEHI, JAVID J · 2019 to 2023
$3.3M
Long-Term Cardiovascular Sequelae of Cancer ImmunotherapiesR01HL155990 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JOHNSON, DOUGLAS B, MOSLEHI, JAVID J · 2021 to 2025
$3.3M
A Patient-Oriented Research Program in Geriatric OncologyK24AG056589 · NIA · UNIVERSITY OF ROCHESTER · PI Supriya G. Mohile · 2018 to 2026
$1.5M
Mentoring the Next Generation of Geriatric Oncology Researchers in Patient-Oriented Research to Improve the Care of Older Adults with CancerK24AG055693 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI WILLIAM DALE · 2018 to 2026
$1.4M
Geriatrics Research: From Bench to BedsideU13AG054139 · NIA · AMERICAN GERIATRICS SOCIETY · PI WHITSON, HEATHER E. · 2016 to 2020
$201k
NCI NIH HHS UG1 CA189961NHLBI NIH HHS R01 HL141466NHLBI NIH HHS R01 HL155990NHLBI NIH HHS R01 HL156021NIA NIH HHS K24 AG055693NIA NIH HHS K24 AG056589NIA NIH HHS R33 AG059206NIA NIH HHS U13 AG054139
6 · The paper itself

Abstract

This report summarizes the presentations, discussions, and recommendations of the most recent American Geriatrics Society and National Institute on Aging research conference, "Cancer and Cardiovascular Disease," on October 18-19, 2021. The purpose of this virtual meeting was to address the interface between cancer and heart disease, which are the two leading causes of death among older Americans. Age-related physiologic changes are implicated in the pathogenesis of both conditions. Emerging data suggest that cancer-related cardiovascular disease (CVD) involves disrupted cell signaling and cellular senescence. The risk factors for CVD are also risk factors for cancer and an increased likelihood of cancer death, and people who have both cancer and CVD do more poorly than those who have only cancer or only CVD. Issues addressed in this bench-to-bedside conference include mechanisms of cancer and CVD co-development in older adults, cardiotoxic effects of cancer therapy, and management of comorbid cancer and CVD. Presenters discussed approaches to ensure equitable access to clinical trials and health care for diverse populations of adults with CVD and cancer, mechanisms of cancer therapy cardiotoxicity, and management of comorbid CVD and cancer, including the role of patient values and preferences in treatment decisions. Workshop participants identified many research gaps and questions that could lead to an enhanced understanding of comorbid CVD and cancer and to better and more equitable management strategies.

Indexed as

Cardiovascular DiseasesGeriatricsNeoplasmsAgedHumansNational Institute on Aging (U.S.)Risk FactorsUnited Statesagingcancercardiotoxicitycardiovascular disease

Identifiers

PMID35689461
PMCPMC9588510
OpenAlexW4282926119

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.