ReviewBJU international2023
Comprehensive review of the use of hydrogel spacers prior to radiation therapy for prostate cancer.
Review in BJU international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Trial
- From Clinical Trials to Clinical Practice-Patterns of Practice Survey on Prostate SABR in Australia and New Zealand.Advances in radiation oncology · 2026Article
- Combined Wide Resection and Bioabsorbable Spacer Placement for High-Dose Postoperative Radiation Therapy in Retroperitoneal Dedifferentiated Liposarcoma: Considerations Regarding Metallic Coil Artifacts.Advances in radiation oncology · 2026Article
- Fournier's Gangrene Following Hydrogel Spacer-related Rectal Ulcer and Fistula in a Patient Undergoing Radiation Therapy for Prostate Cancer.Internal medicine (Tokyo, Japan) · 2026Article
- Hydrogel injection outside of prostate radiation: an overview.Abdominal radiology (New York) · 2026Review
- Article
- Real-World Data on Barrigel and SpaceOAR Rectal Spacers in Prostate Cancer Radiation Therapy: A Comparative Analysis.Advances in radiation oncology · 2026Article
- Real-World Medical Device Reports of SpaceOAR Hydrogel Spacer: Analysis of the Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) Database.Advances in radiation oncology · 2025Article
- Association Between Rectal Spacer Use and Erectile Dysfunction Diagnosis Among Men Receiving Prostate Radiotherapy: US County-Level Analysis.Cancer medicine · 2025Article
- Innovative Applications of Hydrogels in Contemporary Medicine.Gels (Basel, Switzerland) · 2025Review
- Laparoscopic omentopexy as a spacer for carbon-ion radiotherapy in locally advanced pancreatic cancer.Annals of hepato-biliary-pancreatic surgery · 2025Article
- Rectal spacer use and bowel, urinary, and sexual dysfunction diagnosis and related procedures among men receiving prostate radiotherapy: US county-level analysis.World journal of urology · 2025Article
- Article
- The impact of rectal spacers in MR-guided adaptive radiotherapy.Clinical and translational radiation oncology · 2024Article
- Impact of cyclophosphamide on the morphological and histological changes in polyglycolic acid spacers.Journal of radiation research · 2024Article
- One-year clinical outcomes of MR-guided stereotactic body radiation therapy with rectal spacer for patients with localized prostate cancer.World journal of urology · 2024Article
- The march toward single-fraction stereotactic body radiotherapy for localized prostate cancer-Quo Vadimus?World journal of urology · 2023Review
- The Use of Hydrogel-Based Materials for Radioprotection.Gels (Basel, Switzerland) · 2023Review
- Efficacy and Safety of Newly Installed Spot Scanning Proton Beam Therapy for Prostate Cancer.In vivo (Athens, Greece)Article
- Quantifying geometric and dosimetric advantage from the use of rectal spacing in HDR prostate brachytherapy.BrachytherapyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesTo provide a comprehensive narrative review of the published data on the impact of hydrogel spacers on rectal dosimetry and toxicity and to outline the practicalities of inserting hydrogel spacers.
resultsA growing body of evidence suggests that the administration of hydrogel spacers is safe and is associated with limited peri-operative morbidity. The impact on rectal dosimetry has been clearly established and use of hydrogel spacers is associated with reduced rectal morbidity. These results have been corroborated by several Phase II and III clinical trials and subsequent meta-analysis. There are several areas for future research, including the role of hydrogel spacers in prostate stereotactic beam radiotherapy and post-radiotherapy local recurrence.
conclusionsHydrogel spacers provide a low-morbidity method to potential reduce rectal toxicity after radiation therapy in men with prostate cancer. Data outlining sexual function and oncological outcomes are limited to date. Future studies, currently being conducted, may provide further clarification of the role of hydrogel spacers in prostate cancer management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.