ArticleAnnals of neurology2022
Management of Cerebral Venous Thrombosis Due to Adenoviral COVID-19 Vaccination.
Open access · hybridAbstract read
In one paragraph
Article in Annals of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Classification of Platelet-Activating Anti-Platelet Factor 4 Disorders.International journal of laboratory hematology · 2026Review
- Cerebral venous thrombosis: Current management, recent advances and future directions.International journal of stroke : official journal of the International Stroke Society · 2025Review
- Platelet spleen tyrosine kinase is a key regulator of anti-PF4 antibody-induced immunothrombosis.Blood advances · 2025Article
- Surgical and Endovascular Management of Aortic Thrombosis in COVID-19 and Vaccine-Induced Immune Thrombotic Thrombocytopenia.Vascular health and risk management · 2025Review
- Cranioplasty after Decompressive Craniectomy (DC) in a Patient with Intracerebral Hemorrhage after SARS-CoV-2 Vaccination-Related Vaccine-Induced Thrombotic Thrombocytopenia (VITT)-Proposal of a Management Protocol for This Rare Pathological Condition.Journal of clinical medicine · 2024Article
- Outcomes After Decompressive Surgery for Severe Cerebral Venous Sinus Thrombosis Associated or Not Associated with Vaccine-Induced Immune Thrombosis with Thrombocytopenia: A Multicenter Cohort Study.Neurocritical care · 2024Article
- Endovascular treatment of cerebral sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia.European stroke journal · 2024Article
- Bibliometric Analysis of the Composition of Landmark Cerebral Venous Sinus Thrombosis Research.International journal of cerebrovascular disease and stroke · 2024Article
- Imaging and clinical outcomes of COVID-19- vs. non-COVID-19-related cerebral venous thrombosis.Frontiers in stroke · 2024Article
- Anti-PF4 immunothrombosis without proximate heparin or adenovirus vector vaccine exposure.Blood · 2023Article
- Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke.Frontiers of medicine · 2023Review
- Autoimmune Heparin-Induced Thrombocytopenia.Journal of clinical medicine · 2023Review
- Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia in middle-income countries.International journal of stroke : official journal of the International Stroke Society · 2023Article
- Immunohistologic Features of Cerebral Venous Thrombosis Due to Vaccine-Induced Immune Thrombotic Thrombocytopenia.Neurology(R) neuroimmunology & neuroinflammation · 2023Article
- Vaccine-induced immune thrombotic thrombocytopenia: what do we know hitherto?Frontiers in medicine · 2023Review
- Article
- Anti-PF4 antibodies and their relationship with COVID infection.Hematology, transfusion and cell therapyReview
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
105 authors at 20 institutions in 20 countries.
Adrian Scutelnic *Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0001-9053-584X
Katarzyna Krzywicka *Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Joshua MbrohHertie Institute for Clinical Brain Research, Eberhard-Karls University, Tuebingen, Germany.ORCID 0000-0002-0108-9161
Anita van de MunckhofDepartment of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Mayte Sánchez van KammenDepartment of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-5614-9689
Diana Aguiar de SousaCEEM and Institute of Anatomy, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
Erik LindgrenDepartment of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID 0000-0002-7628-5044
Katarina JoodDepartment of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Albrecht GüntherDepartment of Neurology, Jena University Hospital, Jena, Germany.
Sini HiltunenDepartment of Neurology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Jukka PutaalaDepartment of Neurology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-6630-6104
Andreas TiedeClinic for Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Frank MaierDepartment of Neurology, Caritas Hospital Saarbrücken, Saarbrücken, Germany.
Rolf KernDepartment of Neurology, Kempten Hospital, Kempten, Germany.
Thorsten BartschDepartment of Neurology, University Medical Center Schleswig-Holstein, Kiel, Germany.
Katharina AlthausDepartment of Neurology, Ulm University Hospital, Ulm, Germany.
Alfonso CicconeDepartment of Neurology, Carlo Poma Hospital, Azienda Socio Sanitaria Territoriale di Mantova, Mantua, Italy.
Markus WiedmannDepartment of Neurosurgery, Oslo University Hospital, Oslo, Norway.
Mona SkjellandDepartment of Neurosurgery, Oslo University Hospital, Oslo, Norway.
Antonio MedinaDepartment of Neurology, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
Elisa Cuadrado-GodiaDepartment of Neurology, University Hospital del Mar, Barcelona, Spain.
Thomas CoxDepartment of Neurology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Avinash AujayebRespiratory Department, Northumbria Healthcare NHS Foundation Trust, Cramlington, UK.
Nicolas RaposoDepartment of Neurology, Toulouse University Hospital, Toulouse, France.ORCID 0000-0002-9152-4445
Katia GaramboisStroke Unit, University Hospital of Grenoble, Grenoble, France.
Jean-Francois PayenStroke Unit, University Hospital of Grenoble, Grenoble, France.
Fabrice VuillierStroke Unit, University Hospital of Besancon, Besancon, France.
Guillaume FranchineauDepartment of Intensive Care, Centre Hospitalier Intercommunal de Poissy Saint Germain en Laye, Poissy, France.
Serge TimsitNeurology and Stroke Unit, Centre Hospitalier Universitaire de Brest, CHU Brest, Brest, France.ORCID 0000-0003-0346-8576
David BougonDepartment of Critical Care, Annecy Genevois Hospital, Annecy, France.
Marie-Cécile DuboisDepartment of Anesthesia and Intensive Care, University Hospital of Poitiers, Poitiers, France.
Audrey TawaDepartment of Anesthesia and Intensive Care, University Hospital of Rennes, Rennes, France.
Clement TracolDepartment of Neurology, CHU Rennes, Rennes, France.
Emmanuel De MaistreDepartment of Biological Haematology, CHU Dijon, Dijon, France.
Fabrice BonnevilleDepartment of Neuroradiology, Toulouse University Hospital, Toulouse, France.
Caroline VayneDepartment of Hematology and Hemostasis, Tours University Hospital, Tours, France.
Annerose MengelDepartment of Neurology and Stroke, Eberhard-Karls University, Tuebingen, Germany.
Dominik MichalskiDepartment of Neurology, Leipzig University Hospital, Leipzig, Germany.
Johann PelzDepartment of Neurology, Leipzig University Hospital, Leipzig, Germany.
Matthias WittstockDepartment of Neurology, University Hospital Rostock, Rostock, Germany.
Felix BodeDepartment of Neurology, Universitätsklinikum Bonn, Bonn, Germany.
Julian ZimmermannDepartment of Neurology, Universitätsklinikum Bonn, Bonn, Germany.
Judith SchoutenDepartment of Neurology, Rijnstate Hospital Arnhem, Arnhem, The Netherlands.
Alina ButureAcute Stroke Service, Mater Misericordiae University Hospital, Dublin, Ireland.
Sean MurphyAcute Stroke Service, Mater Misericordiae University Hospital, Dublin, Ireland.
Vincenzo PalmaDepartment of Neurology-Stroke Unit, Ospedale del Mare, ASL Napoli 1 Centro, Napoli, Italy.ORCID 0000-0002-5178-7793
Alberto NegroDepartment of Neuroradiology, Ospedale del Mare, Naples, Italy.
Alexander GutschalkDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
Simon NagelDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
Silvia SchoenenbergerDepartment of Neurology, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-3348-6719
Giovanni FrisulloDepartment of Neurology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Carla ZanferrariDepartment of Neurology, Azienda Ospedaliera di Melegnano e della Martesana, Melegnano, Italy.
Francesco GrilloStroke Unit, Department of Clinical and Experimental Medicine, University Hospital G. Martino, Messina, Italy.
Fabrizio GiammelloTranslational Molecular Medicine and Surgery, XXXV Cycle, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.ORCID 0000-0002-2828-1305
Mar Morin MartinDepartment of Neurology, Hospital Complex of Toledo, Toledo, Spain.
Alvaro CerveraDepartment of Neurology, Royal Darwin Hospital, Tiwi, Northern Territory, Australia.
Jim BurrowDepartment of Neurology, Royal Darwin Hospital, Tiwi, Northern Territory, Australia.
Carlos Garcia EsperonDepartment of Neurology, John Hunter Hospital, Newcastle, New South Wales, Australia.ORCID 0000-0001-8843-5890
Beng Lim Alvin ChewDepartment of Neurology, John Hunter Hospital, Newcastle, New South Wales, Australia.
Timothy J KleinigDepartment of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Cristina SorianoDepartment of Neurology, Hospital General de Castellón, Castelló, Spain.
Domenico S ZimatoreDepartment of Neuroradiology, Policlinico di Bari, Bari, Italy.
Marco PetruzzellisDepartment of Neurology, AOU Consorziale Policlinico di Bari, Bari, Italy.
Ahmed ElkadyDepartment of Neurology, Saudi German Hospital, Jeddah, Saudi Arabia.
Miguel S MirandaDepartment of Neurology, Hospital de Cascais Dr José de Almeida, Cascais, Portugal.
João FernandesDepartment of Neurology, Norra Älvsborgs Länssjukhus, Trollhattan, Sweden.
Åslög Hellström VogelDepartment of Internal Medicine, Skåne University Hospital, Lund, Sweden.
Elias JohanssonClinical Science, Neurosciences, Umeå University, Umeå, Sweden.
Anemon Puthuppallil PhilipDepartment of Neurology, Hamilton General Hospital, Hamilton, Ontario, Canada.
Shelagh B CouttsDepartment of Clinical Neurosciences, Radiology, and Community Health Sciences, Foothills Medical Centre, Calgary, Alberta, Canada.
Simerpreet BalDepartment of Clinical Neurosciences, Radiology, and Community Health Sciences, Foothills Medical Centre, Calgary, Alberta, Canada.
Brian BuckDivision of Neurology, University of Alberta Hospital, Edmonton, Alberta, Canada.
Catherine LegaultDepartment of Neurology and Neurosurgery, McGill University Health Centre, Montreal, Quebec, Canada.
Dylan BlacquiereDivision of Neurology, The Ottawa Hospital, Ottawa, Ontario, Canada.
Hans D KatzbergDepartment of Neuromuscular Medicine, Toronto General Hospital, Toronto, Ontario, Canada.
Thalia S FieldDivision of Neurology, University of British Columbia, Vancouver Stroke Program, Vancouver, British Columbia, Canada.
Vanessa DizonnoDepartment of Neurology, Medical University of Graz, Graz, Austria.
Thomas GattringerDepartment of Neurology, Nordwest Hospital, Frankfurt am Main, Germany.ORCID 0000-0002-6065-6576
Christian JacobiDepartment of Neurology, Nordwest Hospital, Frankfurt am Main, Germany.
Annemie DevroyeDepartment of Neurology, University Hospitals Leuven, Leuven, Belgium.
Robin LemmensDepartment of Neurology, University Hospitals Leuven, Leuven, Belgium.
Espen Saxhaug KristoffersenDepartment of Neurology, Akershus University Hospital, Lørenskog, Norway.ORCID 0000-0002-8999-5424
Monica Bandettini di PoggioDepartment of Neuroscience, Policlinic San Martino Hospital, Genoa, Italy.
Masoud GhiasianDepartment of Neurology, Sina Hospital, Hamadan University of Medical Science, Hamadan, Iran.
Theodoros KarapanayiotidesDepartment of Neurology, AHEPA University Hospital, Thessaloniki, Greece.
Sophie ChattertonDepartment of Neurology, St. Vincent's Hospital, Sydney, New South Wales, Australia.
Miriam WronskiRoyal North Shore Hospital, Sydney, New South Wales, Australia.
Karl NgDepartment of Neurology and Clinical Neurophysiology, Royal North Shore Hospital and The University of Sydney, Sydney, New South Wales, Australia.
Robert KahnisDepartment of Neurology, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany.
Thomas GeeraertsDepartment of Anaesthesiology and Critical Care, University Toulouse 3-Paul-Sabatier, University Hospital of Toulouse, Hôpital Pierre-Paul Riquet, CHU Toulouse-Purpan, Toulouse, France.
Peggy ReinerService de neurologie, hôpital Lariboisière Université Paris-7, AP-HP, Paris Cedex 10, France.
Charlotte CordonnierUniversity of Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Lille, France.ORCID 0000-0002-5697-6892
Saskia MiddeldorpDepartment of Internal Medicine & Radboud Institute of Health Sciences (RIHS), Radboud University Medical Center, Nijmegen, The Netherlands.
Marcel LeviNational Institute for Health Research University College London Hospitals (UCLH) Biomedical Research Centre, London, UK.
Eric C M van GorpDepartment of Viroscience, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Diederik van de BeekDepartment of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Justine BrodardDepartment of Hematology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Johanna A Kremer HovingaDepartment of Hematology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Marieke J H A KruipDepartment of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Turgut TatlisumakDepartment of Neurology & Stroke, Eberhard-Karls University, Tuebingen, Germany.
José M FerroInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Jonathan M CoutinhoDepartment of Neurology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Marcel ArnoldDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Sven Poli *Hertie Institute for Clinical Brain Research, Eberhard-Karls University, Tuebingen, Germany.
Mirjam R Heldner *Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-3594-2159
Amsterdam University Medical Centers · NLUniversity of Bern · CHHeidelberg University · DEAzienda Universitaria Ospedaliera Consorziale - Policlinico Bari · ITCentre Hospitalier Universitaire de Grenoble · FRErasmus MC · NLFoothills Medical Centre · CAJohn Hunter Hospital · AUKrankenhaus Nordwest · DEKU Leuven · BEMater Misericordiae University Hospital · IEOslo University Hospital · NORoyal Darwin Hospital · AUSahlgrenska University Hospital · SEUniversité Fédérale de Toulouse Midi-Pyrénées · FRUniversity Hospital Bonn · DEUniversity Hospital Leipzig · DEUniversity of Helsinki · FIUniversity of Lisbon · PTUniversity of Tübingen · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCerebral venous thrombosis (CVT) caused by vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare adverse effect of adenovirus-based severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccines. In March 2021, after autoimmune pathogenesis of VITT was discovered, treatment recommendations were developed. These comprised immunomodulation, non-heparin anticoagulants, and avoidance of platelet transfusion. The aim of this study was to evaluate adherence to these recommendations and its association with mortality.
methodsWe used data from an international prospective registry of patients with CVT after the adenovirus-based SARS-CoV-2 vaccination. We analyzed possible, probable, or definite VITT-CVT cases included until January 18, 2022. Immunomodulation entailed administration of intravenous immunoglobulins and/or plasmapheresis.
resultsNinety-nine patients with VITT-CVT from 71 hospitals in 17 countries were analyzed. Five of 38 (13%), 11 of 24 (46%), and 28 of 37 (76%) of the patients diagnosed in March, April, and from May onward, respectively, were treated in-line with VITT recommendations (p < 0.001). Overall, treatment according to recommendations had no statistically significant influence on mortality (14/44 [32%] vs 29/55 [52%], adjusted odds ratio [OR] = 0.43, 95% confidence interval [CI] = 0.16-1.19). However, patients who received immunomodulation had lower mortality (19/65 [29%] vs 24/34 [70%], adjusted OR = 0.19, 95% CI = 0.06-0.58). Treatment with non-heparin anticoagulants instead of heparins was not associated with lower mortality (17/51 [33%] vs 13/35 [37%], adjusted OR = 0.70, 95% CI = 0.24-2.04). Mortality was also not significantly influenced by platelet transfusion (17/27 [63%] vs 26/72 [36%], adjusted OR = 2.19, 95% CI = 0.74-6.54).
conclusionsIn patients with VITT-CVT, adherence to VITT treatment recommendations improved over time. Immunomodulation seems crucial for reducing mortality of VITT-CVT. ANN NEUROL 2022;92:562-573.
Indexed as
COVID-19Intracranial ThrombosisVenous ThrombosisAdenoviridaeAnticoagulantsCOVID-19 VaccinesHumansImmunoglobulins, IntravenousSARS-CoV-2VaccinationAnticoagulantsCOVID-19 VaccinesImmunoglobulins, Intravenous
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.