Effect of time restricted feeding on anthropometric measures, eating behavior, stress, and brain-derived neurotrophic factor (BDNF) and lipopolysaccharide-binding protein (LBP) levels in women with overweight/obesity and food addiction: a study protocol for a randomized clinical trial.

Hanieh Irani, Banafsheh Khodami, Behnaz Abiri, Atoosa Saidpour

Open access · goldAbstract readClinical Trial Protocol

In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 56% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hanieh IraniDepartment of Nutrition, Faculty of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Banafsheh KhodamiDepartment of Nutrition, Faculty of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Behnaz AbiriObesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Atoosa SaidpourDepartment of Nutrition, Faculty of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. atoosa.saidpour@gmail.com.

Shahid Beheshti University of Medical Sciences · IRNational Nutrition and Food Technology Research Institute · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFood addiction is one of the behavioral factors that play an important role in the pathogenesis of obesity. Much evidence is available suggesting intestinal microbiomes can play a role in eating behavior, body composition, and BDNF levels, and they can be modified by time-restricted feeding (TRF). So, this study will aim to evaluate the effect of TRF on anthropometric measures, eating behavior, stress, and serum BDNF and LBP levels in women with overweight/obesity and food addiction.

methodsWe will carry out a randomized clinical trial for 8 weeks to evaluate the effect of a TRF on anthropometric measures, eating behavior, stress level, serum BDNF and LBP levels in women with overweight/obesity and food addiction. DISCUSSION: Given the effect of BDNF on regulating eating behavior and body weight and the effect of dietary restrictions on BDNF and the gut microbiome, the TRF diet could possibly be a new way to successfully manage weight through modifying BDNF in people with eating disorders, including food addiction.

trial registrationIranian Registry of Clinical Trials IRCT20131228015968N7 . Registered on 25 October 2020.

Indexed as

Food AddictionOverweightAcute-Phase ProteinsBrain-Derived Neurotrophic FactorCarrier ProteinsFastingFeeding BehaviorFemaleHumansIranLipopolysaccharide-Binding ProteinMembrane GlycoproteinsObesityRandomized Controlled Trials as TopicAcute-Phase ProteinsBrain-Derived Neurotrophic FactorCarrier ProteinsLipopolysaccharide-Binding ProteinMembrane GlycoproteinsBDNFEating behaviorFood addictionGut microbiomeIntermittent fastingLBPTime-restricted feedingWeight loss

Identifiers

PMID35689257

DOI10.1186/s13063-022-06439-x

PMCPMC9188095

OpenAlexW4281774404

What OpenQuestion holds

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LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.